V beta profiles in African children with acute cerebral or uncomplicated malaria: very focused changes among a remarkable global stability
| Autor: | John K. A. Tetteh, Philippe Boeuf, Odile Mercereau-Puijalon, Séverine Loizon, Bartholomew D. Akanmori, Lars Hviid, George Obeng-Adjei, Jørgen A. L. Kurtzhals, Bamenla Q. Goka, Christophe Rogier, Charlotte Behr |
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| Přispěvatelé: | Immunologie moléculaire des parasites, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), University of Ghana, Rigshospitalet [Copenhagen], Copenhagen University Hospital, Institut de Médecine Tropicale du Service de Santé des Armées (IMTSSA), Service de Santé des Armées, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
CD4-Positive T-Lymphocytes
media_common.quotation_subject T cell Immunology Malaria Cerebral Receptors Antigen T-Cell Biology Microbiology Asymptomatic Ghana Pathogenesis 03 medical and health sciences 0302 clinical medicine T-Lymphocyte Subsets parasitic diseases medicine Superantigen Animals Humans Beta (finance) 030304 developmental biology media_common 0303 health sciences Convalescence Infant medicine.disease Flow Cytometry 3. Good health Infectious Diseases medicine.anatomical_structure Cerebral Malaria Child Preschool [SDV.IMM]Life Sciences [q-bio]/Immunology medicine.symptom Malaria 030215 immunology |
| Zdroj: | Microbes and Infection Microbes and Infection, Elsevier, 2007, 9 (11), pp.1252-9. ⟨10.1016/j.micinf.2007.05.019⟩ Microbes and Infection, 2007, 9 (11), pp.1252-9. ⟨10.1016/j.micinf.2007.05.019⟩ |
| ISSN: | 1286-4579 |
| Popis: | International audience; T cells are thought to play a critical role in cerebral malaria pathogenesis. However, available evidences are restricted to rodent models in which V beta specific T cell expansion has been associated with neurological syndrome suggesting involvement of superantigens or dominant antigens. Using flow cytometry, we studied the peripheral V beta T cell repertoire of Ghanaian children with cerebral malaria, uncomplicated malaria and asymptomatic control children, to look for either expansion or deletion of specific V beta associated with cerebral malaria. At admission, the general pattern of the repertoire of the patients was very similar, with no major distortion compared to the control group a part a significant increase of the frequency of the V beta 21.3 subset correlating with disease severity and attributed to the CD4 subset. During convalescence very limited fluctuations were observed including a significant decrease of the V beta 21.3 subset and increase of the V beta 20 subset, a subset not detected at admission. The remarkable stability of the V beta repertoire observed in acute malaria either cerebral or uncomplicated argues against the idea that cerebral malaria would result from a T cell-mediated inflammatory shock syndrome driven by some dominant super-antigenic activity(ies). The significance of the reproducible increase of the CD4+V beta 21.3T cell subset deserves further investigations. |
| Databáze: | OpenAIRE |
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