Functionalization of 2,3,4,5-Tetrahydro-1,5-benzodiazepin-2(1 H )-ones by Electrophilic Aromatic Substitution

Autor:	Ausra Vektariene, Zita Stumbreviciute, Kazimieras Konstantinavicius, Lidija Kosychova, Benedikta D. Puodziunaite, Regina Janciene
Rok vydání:	2003
Předmět:	Electrophilic substitution chemistry.chemical_compound Hydrolysis chemistry Nitration Surface modification Organic chemistry General Medicine General Chemistry Orientation (graph theory) Electrophilic aromatic substitution Medicinal chemistry
Zdroj:	Monatshefte f�r Chemie / Chemical Monthly. 134:1629-1639
ISSN:	1434-4475 0026-9247
DOI:	10.1007/s00706-003-0056-7
Popis:	Highly substituted, novel, 8- and 9-nitro-2,3,4,5-tetrahydro-1,5-benzodiazepin-2(1H)-ones were obtained by direct nitration of the 7-bromo-5-trifluoroacetyl (or formyl)-substituted tetrahydrobenzodiazepinones. Alkaline and acidic hydrolysis of the novel mononitro derivatives was examined. Semiempirical AM1 calculations of aromatic substituents orientation in the nitration products are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3f3ee9157f1f77a21834067d678341 https://doi.org/10.1007/s00706-003-0056-7 Zobrazit plný text záznamu Full text from SpringerLink