Glutamatergic channels in locust muscle show a wide time range of desensitization and resensitization characteristics
| Autor: | R. L. Ramsey, P.N.R. Usherwood, Josef Dudel, H. Hatt, Ch. Franke |
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| Rok vydání: | 1990 |
| Předmět: |
Membrane potential
biology General Neuroscience medicine.medical_treatment Muscles Time constant Glutamate receptor Glutamic Acid Anatomy Grasshoppers In Vitro Techniques biology.organism_classification Ion Channels Membrane Potentials Electrophysiology Glutamatergic Kinetics Glutamates medicine Biophysics Animals Ion channel Locust Desensitization (medicine) |
| Zdroj: | Neuroscience letters. 114(2) |
| ISSN: | 0304-3940 |
| Popis: | Outside-out patches of membrane were excised from locust muscle. 10 mM L-glutamate applied to such patches in short pulses elicited rapidly a peak of channel opening, followed by desensitization with time constants between 1 ms and 20 ms for different channel subtypes. Slowly rising glutamate concentrations could produce almost complete desensitization without any channel openings. Desensitization thus proceeds from a closed channel state, prior to channel opening. Resensitization, i.e. recovery from desensitization, was tested by applying pairs of glutamate pulses, varying the pulse interval. Resensitization has a biphasic time course. While in rapidly desensitizing channels more than 50% of resensitization was achieved within a few milliseconds, in slowly desensitizing channels resensitization took seconds. |
| Databáze: | OpenAIRE |
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