Influence of vascular risk factors on executive function among an age-homogeneous elderly cohort
| Autor: | Walter Krugluger, Wolfgang Krampla, Nazanin Sédille-Mostafaie, Peter Fischer, Sonja Zehetmayer |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Neurology Psychometrics Population Neuropsychological Tests Cohort Studies Executive Function Neuroimaging Risk Factors Diabetes mellitus Internal medicine medicine Humans Vascular Diseases education Psychiatry Biological Psychiatry Depression (differential diagnoses) Aged education.field_of_study Brain medicine.disease White Matter Hyperintensity Psychiatry and Mental health Logistic Models Area Under Curve Austria Cohort Female Neurology (clinical) Psychology Executive dysfunction |
| Zdroj: | Journal of Neural Transmission. 122:1323-1328 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-015-1389-1 |
| Popis: | The pathogenesis of executive dysfunction in geriatric depression remains uncertain although causal bidirectional relationships with depression have been discussed. Previous studies have described a potential link with ‘vascular depression’. In this study, we investigate the influence of vascular risk factors and magnetic resonance imaging markers of structural brain ageing, such as increasing deep white matter hyperintensities (DWMH), on executive function in an age-homogeneous population-based study cohort. A total of 606 participants of identical age (75.8 years; standard deviation 0.45 years) took part in the baseline investigation of the Vienna Transdanube Ageing (VITA) study. Each participant underwent a full psychometric examination with standardised neuroimaging and clinical chemistry investigations. Participants were re-examined with the same protocol after exactly 30 and 60 months. Data refer to the individuals who completed the examination at baseline. In the ordinal logistic regression, fewer years of education (P |
| Databáze: | OpenAIRE |
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