Relaxation Kinetic Study of Eudragit® NM30D Film Based on Complex Modulus Formalism
| Autor: | Sai Sumana Penumetcha, Stephen R. Byrn, Kenneth R. Morris |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Permittivity
Materials science Drug Compounding Analytical chemistry Pharmaceutical Science Modulus Thermodynamics Dielectric Aquatic Science Differential scanning calorimetry Polymethacrylic Acids Elastic Modulus Drug Discovery Dynamic modulus Elastic modulus Ecology Evolution Behavior and Systematics Drug Carriers Ecology Calorimetry Differential Scanning Molecular Structure General Medicine Acrylates Models Chemical Thermogravimetry Relaxation (physics) Glass transition Agronomy and Crop Science Research Article |
| Popis: | This study is aimed at resolving and characterizing the primary (α) and secondary relaxations (β) in Eudragit® NM30D film based on apparent activation energies derived from complex modulus formalism using dielectric analysis (DEA). The glass transition (T g) of the film was determined using differential scanning calorimetry (DSC). The α relaxation corresponding to T g and the β relaxations occurring below T g were probed using DEA. The occurrence of α and β relaxations in Eudragit® NM30D film was elucidated using the complex modulus of the dielectric response employing loss modulus and permittivity data. Activation energies of these relaxations and the fundamental frequency so determined support the assignment of the relaxation pattern in the Eudragit® NM30D film. DEA methodology of the complex modulus formalism is a useful tool for differentiating the α and β relaxation kinetics in Eudragits® not easily studied using traditional thermal methods such as DSC. The kinetics associated with α and β relaxations so determined will provide formulation design support for solid orals that incorporate Eudragit® polymers. As mobility changes can affect stability and diffusion, the dipolar α and β relaxations revealed through DEA analysis may enable a better correlation to functionality of Eudragit® based pharmaceutical dosage forms. |
| Databáze: | OpenAIRE |
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