Retrospective Comparison of Clinical and Angiographic Outcomes After Sirolimus-Eluting and Bare-Metal Stent Implantation in 312 Consecutive, Nonrandomized Severely Calcified Lesions Using a Rotablator
| Autor: | Michihiro Yoshimura, Kamon Imai, Teruhiko Suzuki, Toshio Hasuda, Yosuke Nakano, Makoto Mutoh, Takeyuki Kubota, Hiroshi Sakamoto, Tetsuya Ishikawa, Akira Endoh |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Bare-metal stent medicine.medical_specialty medicine.medical_treatment Coronary Artery Disease Coronary Angiography Severity of Illness Index Coronary Restenosis Restenosis medicine Clinical endpoint Humans Angioplasty Balloon Coronary Aged Retrospective Studies Aged 80 and over Sirolimus business.industry Proportional hazards model Hazard ratio Stent Drug-Eluting Stents Retrospective cohort study General Medicine Odds ratio medicine.disease Surgery Treatment Outcome Female Radiology Cardiology and Cardiovascular Medicine business Immunosuppressive Agents |
| Zdroj: | International Heart Journal. 52:65-71 |
| ISSN: | 1349-3299 1349-2365 |
| DOI: | 10.1536/ihj.52.65 |
| Popis: | In order to compare the long-term clinical and angiographic outcomes after sirolimus-eluting stent (SES) and bare-metal stent (BMS) placement in severely calcified lesions using a rotablator under the widespread indication of SES, a nonrandomized examination of 312 consecutive lesions after successful implantation of a BMS (99 lesions in 84 patients; from January 2003) or SES (213 in 167; from September 2004) using a rotablator was conducted. The lesion-based primary endpoints (cardiac death and nonfatal recurrent myocardial infarction) and the secondary endpoint [binary restenosis (BR) (diameter stenosis > 50%) at follow-up angiography] were retrospectively determined in August 2010. The incidence of primary endpoint in the SES group (2.3%; mean follow-up period of 1289 ± 526 days) was significantly lower than that in the BMS group (7.1%; P = 0.043; 1803 ± 887 days), although the several variables related to the endpoints were present in the SES group. Cox proportional hazard model analysis revealed that SES was not significantly related to a primary endpoint [hazard ratio of 0.42 (95% CI, 0.073-2.42; P = 0.33)]. The incidence of BR in the SES group (21.3%) was not significantly different from that in the BMS group (27.1%) (P = 0.33). Multivariate logistic regression analysis revealed that SES was not a significant predictor of BR [Odds ratio of 0.78 (95% CI, 0.41-1.51; P = 0.47)]. Thus, although the results of the present retrospective nonrandomized study demonstrate the long-term safety of SES for calcified lesions using a rotablator in daily practice, SES did not show a benefit for the angiographic outcomes compared to BMS. |
| Databáze: | OpenAIRE |
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