Inhibitory action of sphingosine, sphinganine and dexamethasone on glucose uptake: Studies with hydrogen peroxide and phorbol ester
| Autor: | Mark Hill, Darrell K. Murray, Don H. Nelson |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Glucose uptake medicine.medical_treatment Dexamethasone General Biochemistry Genetics and Molecular Biology Cell Line chemistry.chemical_compound Sphingosine Internal medicine medicine General Pharmacology Toxicology and Pharmaceutics Glucocorticoids Protein kinase C Kinase Insulin Glucose transporter Biological Transport Hydrogen Peroxide General Medicine Fibroblasts Sphingolipid Glucose Endocrinology chemistry Tetradecanoylphorbol Acetate Glucocorticoid medicine.drug |
| Zdroj: | Life Sciences. 46:1843-1849 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(90)90236-k |
| Popis: | The mechanism of the inhibitory action of glucocorticoids on glucose uptake is incompletely understood. Treatment with corticosteroids of cells in which glucose uptake is stimulated at insulin postbinding and postreceptor sites may clarify the site of the steroid inhibitory action. Hydrogen peroxide, which has been shown to stimulate the insulin receptor tyrosine kinase, and phorbol myristate acetate (PMA) which stimulates protein kinase C were, therefore, used as stimulators of glucose transport in this study. These studies demonstrate that dexamethasone and the sphingoid bases, sphinganine and sphingosine, inhibit glucose uptake that has been stimulated at either the receptor kinase or protein kinase C level in both 3T3-L1 and 3T3-C2 cells. These data confirm glucocorticoid inhibitory action at a post binding level and support the suggestion that some corticosteroid inhibitory effects may be mediated by an action on sphingolipid metabolism. |
| Databáze: | OpenAIRE |
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