Early Bactericidal Activity of Paromomycin (Aminosidine) in Patients with Smear-Positive Pulmonary Tuberculosis
| Autor: | H. I. Seifart, D. P. Parkin, Peter R. Donald, Thomas P. Kanyok, Larry H. Danziger, F J Botha, F. A. Sirgel, B. W. Van de Wal, J. S. Maritz, D. A. Mitchison, Amour Venter |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
medicine.medical_specialty Tuberculosis Adolescent Paromomycin medicine.drug_class Antibiotics Colony Count Microbial Bacillus Pilot Projects Clinical Therapeutics Gastroenterology Mycobacterium tuberculosis Internal medicine medicine Humans Pharmacology (medical) Tuberculosis Pulmonary Antibacterial agent Pharmacology biology Aminoglycoside biology.organism_classification medicine.disease Anti-Bacterial Agents Surgery Infectious Diseases Streptomycin Smear Layer Sputum medicine.symptom medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 44:3285-3287 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.44.12.3285-3287.2000 |
| Popis: | The early bactericidal activity of the aminoglycoside paromomycin (aminosidine) in doses of 7.5 and 15 mg/kg of body weight was measured in 22 patients with previously untreated smear-positive pulmonary tuberculosis. The fall in log 10 CFU per milliliter of sputum per day during the first 2 days of treatment for 7 patients receiving a paromomycin dosage of 7.5 mg/kg/day was 0.066, with a standard deviation (SD) of 0.216 and confidence limits from −0.134 to 0.266, and that for 15 patients receiving 15 mg/kg/day was 0.0924, with an SD of 0.140 and confidence limits from 0.015 to 0.170. The difference between the mean and zero was not significant for the 7.5-mg/kg dose group but was significant for the 15-mg/kg dose group ( t = 2.55, P = 0.023). Since paromomycin has no cross-resistance with streptomycin and has no greater toxicity than other aminoglycosides, these results suggest that it has the potential to substitute for streptomycin in antituberculosis regimens and may be a particularly valuable addition to the drug armamentarium for the management of multidrug-resistant tuberculosis. |
| Databáze: | OpenAIRE |
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