Cardiac Obesity and Cardiac Cachexia: Is There a Pathophysiological Link?
Autor: | Ivica Bošnjak, Diana Delić-Brkljačić, Kristina Selthofer-Relatić, Aleksandar Kibel |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Heart / physiopathology
medicine.medical_specialty lcsh:Internal medicine Aging Cachexia Article Subject Heart Diseases Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Disease Review Article 030204 cardiovascular system & hematology cachexia heart failure obesity 03 medical and health sciences 0302 clinical medicine Biomarkers / metabolism Diabetes mellitus Internal medicine Diabetic cardiomyopathy Heart Failure / physiopathology medicine Humans Cachexia / physiopathology lcsh:RC31-1245 Heart Failure / metabolism Heart Failure Ischemic cardiomyopathy Ejection fraction business.industry Atrial fibrillation Heart medicine.disease Hypertensive heart disease Cachexia / etiology Obesity Abdominal / complications Heart Diseases / etiology Heart Failure / etiology Heart failure Obesity Abdominal Cardiology cardiovascular system business Biomarkers Heart Diseases / physiopathology |
Zdroj: | Journal of Obesity Journal of Obesity, Vol 2019 (2019) |
Popis: | Obesity is a risk factor for cardiometabolic and vascular diseases like arterial hypertension, diabetes mellitus type 2, dyslipidaemia, and atherosclerosis. A special role in obesity-related syndromes is played by cardiac visceral obesity, which includes epicardial adipose tissue and intramyocardial fat, leading to cardiac steatosis; hypertensive heart disease; atherosclerosis of epicardial coronary artery disease; and ischemic cardiomyopathy, cardiac microcirculatory dysfunction, diabetic cardiomyopathy, and atrial fibrillation. Cardiac expression of these changes in any given patient is unique and multimodal, varying in clinical settings and level of expressed changes, with heart failure development depending on pathophysiological mechanisms with preserved, midrange, or reduced ejection fraction. Progressive heart failure with misbalanced metabolic and catabolic processes will change muscle, bone, and fat mass and function, with possible changes in the cardiac fat state from excessive accumulation to reduction and cardiac cachexia with a worse prognosis. The question we address is whether cardiac obesity or cardiac cachexia is to be more feared. |
Databáze: | OpenAIRE |
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