Cardiac Obesity and Cardiac Cachexia: Is There a Pathophysiological Link?

Autor: Ivica Bošnjak, Diana Delić-Brkljačić, Kristina Selthofer-Relatić, Aleksandar Kibel
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Heart / physiopathology
medicine.medical_specialty
lcsh:Internal medicine
Aging
Cachexia
Article Subject
Heart Diseases
Endocrinology
Diabetes and Metabolism

030209 endocrinology & metabolism
Disease
Review Article
030204 cardiovascular system & hematology
cachexia
heart failure
obesity

03 medical and health sciences
0302 clinical medicine
Biomarkers / metabolism
Diabetes mellitus
Internal medicine
Diabetic cardiomyopathy
Heart Failure / physiopathology
medicine
Humans
Cachexia / physiopathology
lcsh:RC31-1245
Heart Failure / metabolism
Heart Failure
Ischemic cardiomyopathy
Ejection fraction
business.industry
Atrial fibrillation
Heart
medicine.disease
Hypertensive heart disease
Cachexia / etiology
Obesity
Abdominal / complications

Heart Diseases / etiology
Heart Failure / etiology
Heart failure
Obesity
Abdominal

Cardiology
cardiovascular system
business
Biomarkers
Heart Diseases / physiopathology
Zdroj: Journal of Obesity
Journal of Obesity, Vol 2019 (2019)
Popis: Obesity is a risk factor for cardiometabolic and vascular diseases like arterial hypertension, diabetes mellitus type 2, dyslipidaemia, and atherosclerosis. A special role in obesity-related syndromes is played by cardiac visceral obesity, which includes epicardial adipose tissue and intramyocardial fat, leading to cardiac steatosis; hypertensive heart disease; atherosclerosis of epicardial coronary artery disease; and ischemic cardiomyopathy, cardiac microcirculatory dysfunction, diabetic cardiomyopathy, and atrial fibrillation. Cardiac expression of these changes in any given patient is unique and multimodal, varying in clinical settings and level of expressed changes, with heart failure development depending on pathophysiological mechanisms with preserved, midrange, or reduced ejection fraction. Progressive heart failure with misbalanced metabolic and catabolic processes will change muscle, bone, and fat mass and function, with possible changes in the cardiac fat state from excessive accumulation to reduction and cardiac cachexia with a worse prognosis. The question we address is whether cardiac obesity or cardiac cachexia is to be more feared.
Databáze: OpenAIRE
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