Changes in acid secretion over the years. A 30-year longitudinal study
| Autor: | Tigler-Wybrandi Na, Gary Trey, Bank S, Jeanne Louw, Marks In, Sipponen P, Novis Bh, K. Jaskiewicz |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Aging Atrophic gastritis Biopsy Gastroenterology Gastric Acid Basal (phylogenetics) chemistry.chemical_compound Internal medicine medicine Humans Longitudinal Studies medicine.diagnostic_test biology Helicobacter pylori business.industry Stomach Middle Aged biology.organism_classification medicine.disease medicine.anatomical_structure chemistry Gastric acid Female Gastritis medicine.symptom business Histamine |
| Zdroj: | Journal of clinical gastroenterology. 25(3) |
| ISSN: | 0192-0790 |
| Popis: | We studied the effect of aging on gastric acid secretion in 11 physicians who had augmented histamine tests while at medical school in 1962. One of them had a duodenal ulcer at the time. The augmented histamine test was repeated in 1991 and, in addition, upper gastrointestinal endoscopy was done to exclude peptic ulcer and to obtain biopsies for histologic analysis and assessment of Helicobacter pylori status. The mean basal acid output decreased from 7.3 to 1.9 mEq/hr during the 30-year period of follow-up (p < 0.001), and the mean maximum acid output decreased from 29.9 to 20.3 mEq/hr (p < 0.01). The maximum acid output data showed a profound decrease in 4 of the 11 participants, a lesser decrease in 4, and a minimal increase in the remaining 3. Histologic analysis suggested a greater likelihood of atrophic gastritis, H. pylori infection, or both in participants showing a pronounced decrease in acid secretion with aging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|