Molecular Biology of Medulloblastoma Therapy
| Autor: | Lisa-Marie Sturla, Scott L. Pomeroy |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Patched
Pathology medicine.medical_specialty Brain tumor Computational biology Biology medicine.disease_cause Risk Assessment chemistry.chemical_compound Molecular marker Biomarkers Tumor medicine Humans Receptors Growth Factor Tissue Collection Growth Substances Medulloblastoma Brain Neoplasms Wnt signaling pathway General Medicine medicine.disease Cell Transformation Neoplastic chemistry Pediatrics Perinatology and Child Health Surgery Neurology (clinical) Carcinogenesis Cell signaling pathways |
| Zdroj: | Pediatric Neurosurgery. 39:299-304 |
| ISSN: | 1423-0305 1016-2291 |
| DOI: | 10.1159/000075257 |
| Popis: | Molecular biological studies have created a new understanding of medulloblastomas, revealing key cell signaling pathways that promote tumor growth. These studies have identified molecular markers that can serve as prognostic indicators and which will provide therapeutic targets in the very near future. In contrast to conventional histological techniques, molecular biological methods are designed to detect highly unstable molecules degraded by conventional tissue collection and fixation protocols. Consequently, a new approach to tissue collection is required for molecular analysis as we enter the next era of brain tumor therapy. |
| Databáze: | OpenAIRE |
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