Long term effect on IOP of a stainless steel glaucoma drainage implant (Ex-PRESS) in combined surgery with phacoemulsification

Autor: A Messas-Kaplan, S Levartovsky, F De Feo, Michael Belkin, Philippe Denis, Carlo Enrico Traverso, Alain M. Bron, Eric Sellem, Z Zagorski, F. Badalà
Přispěvatelé: University of Genova, Medical Center, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Centre Ophtalmologique Kleber, Lublin University, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Goldschleger Eye Research Institute, Partenaires INRAE
Jazyk: angličtina
Rok vydání: 2005
Předmět:
medicine.medical_specialty
Intraocular pressure
Visual acuity
Open angle glaucoma
genetic structures
Organes des sens
implant
medicine.medical_treatment
glaucoma filtering surgery
Sensory Organs
Glaucoma
Médecine humaine et pathologie
Clinical Science - Extended Reports
Cellular and Molecular Neuroscience
Ophthalmology
medicine
émulsification
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Lost to follow-up
Prospective cohort study
ex-PRESS implant
business.industry
fungi
technology
industry
and agriculture
Phacoemulsification
medicine.disease
Sensory Systems
eye diseases
Surgery
glaucoma
phacoemulsification
glaucome
phénomènes physiologiques oculaires
chirurgie ophtalmologique
Human health and pathology
Implant
sense organs
medicine.symptom
business
intraocular pressure
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: British Journal of Ophthalmology 4 (89), 425-429. (2005)
British Journal of Ophthalmology
British Journal of Ophthalmology, BMJ Publishing Group, 2005, 89 (4), pp.425-429. ⟨10.1136/bjo.2004.058032⟩
ISSN: 0007-1161
1468-2079
DOI: 10.1136/bjo.2004.058032⟩
Popis: Aim: To evaluate the efficacy and safety of a stainless steel miniature glaucoma drainage device (Ex-PRESS R50) for the surgical treatment of primary open angle glaucoma (POAG) and cataract when combined with phacoemulsification. Methods: Clinical, prospective, multicentre, single treatment arm, non-randomised, non-masked study. The Ex-PRESS device was implanted at the limbus under a conjunctival flap. Phacoemulsification cataract extraction and in the bag IOL implantation were performed through clear cornea temporally. Primary outcome: IOP change; secondary outcomes: side effects and VA changes. Results: 26 eyes of 25 patients were implanted with the device. The mean (SD) follow up was 23.9 (10.4) months and the mean age was 75.1 (7.1) years. 17/26 eyes have more than 3 years of follow up. One case was discontinued because of device removal, one because of death, and three were lost to follow up. Efficacy: preoperative IOP was 21 (4) mm Hg; at 1, 2, and 3 years IOP was 15.3 (3.1) mm Hg (35% reduction), 16.6 (2.7) mm Hg (29% reduction), and 16 (2.6) mm Hg (22% reduction) respectively. Kaplan-Meyer determined overall success rate (IOP ⩽21 mm Hg at the last visit with or without medications) as 76.9%. The number of antiglaucoma medications was reduced by 95% at year 1. Only six patients (23%) were taking IOP lowering treatment at their last visit, five with one medication and one with two medications. Side effects: early postoperative complications were clinically mild and included six cases of hypotony (IOP Conclusions: The Ex-PRESS implant, combined with phacoemulsification cataract extraction, is clinically safe and effective, maintaining in the long term a large reduction in IOP and in the number of antiglaucoma medications.
Databáze: OpenAIRE
Externí odkaz: