Hypocalcemic Effect of Osteoclastogenesis Inhibitory Factor/Osteoprotegerin in the Thyroparathyroidectomized Rat
| Autor: | Kanji Higashio, Takuhiko Akatsu, Naokazu Nagata, Kazuo Motoyoshi, Michiko Yamamoto, Eisuke Tsuda, Miyuki Nishikawa, Shinichi Mochizuki, Takehiko Murakami |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Calcitriol Injections Subcutaneous Receptors Cytoplasmic and Nuclear Parathyroid hormone chemistry.chemical_element Calcium Receptors Tumor Necrosis Factor Rats Sprague-Dawley Excretion Endocrinology Osteoprotegerin Osteoclast In vivo Internal medicine medicine Animals Humans Glycoproteins Parathyroidectomy Hypocalcemia Osmolar Concentration Recombinant Proteins Urinary calcium Rats medicine.anatomical_structure chemistry Parathyroid Hormone Thyroidectomy Cattle medicine.drug |
| Zdroj: | Endocrinology. 139:4012-4015 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.139.9.6290 |
| Popis: | Osteoclastogenesis inhibitory factor (OCIF), also termed as osteoprotegerin (OPG), is a soluble member of the tumor necrosis factor receptor family. Although OCIF/OPG is shown to inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo, its effect on serum calcium level remains to be determined. In this study we examined the acute effect of OCIF on thyroparathyroidectomized rats whose serum calcium concentrations were raised either by exogenous PTH or 1,25-(OH)2D3. When OCIF was administered at the start of PTH infusion, it attenuated the initial rise in serum calcium. When OCIF was administered into rats with established hypercalcemia, it decreased serum calcium rapidly (within 2 hr) and dramatically. OCIF did not increase urinary calcium excretion. These findings, especially the rapid onset of its hypocalcemic effect, suggest that OCIF not only inhibits the formation of osteoclasts but also affects the function and/or survival of mature osteoclasts at doses used in this study. |
| Databáze: | OpenAIRE |
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