The oxytocin system of mice and men-Similarities and discrepancies of oxytocinergic modulation in rodents and primates
| Autor: | Gustav F. Jirikowski, Ferdinand Althammer, Valery Grinevich |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology Autism Spectrum Disorder Neuropeptide Biology Oxytocin Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience Mice Endocrinology medicine Animals Humans Neuropeptides Brain Evolution of mammals medicine.disease Disease Models Animal 030104 developmental biology Autism spectrum disorder Fish Autism Neuroscience medicine.drug |
| Zdroj: | Peptides. 109 |
| ISSN: | 1873-5169 |
| Popis: | Nonapeptides and their respective receptors have been conserved throughout evolution and display astonishing similarities among the animal kingdom. They can be found in worms, birds, fish, amphibians, reptiles and mammals, including rodents, non-human primates and humans. In particular, the neuropeptide oxytocin (OT) has attracted the attention of scientists due to its profound effects on social behavior. However, although both the neuropeptide and its receptor are identical in rodents and primates, the effects of OT vary greatly in the two species. Here, we provide a brief overview about OT's role in the evolution of mammals and provide reasons for the manifold effects of OT within the brain with a particular focus on the discrepancy of OT's effects in rodents and primates. In addition, we suggest new approaches towards improvement of translatability of scientific studies and highlight the most recent advances in animal models for autism spectrum disorder, a disease, in which the normal function of the OT system seems to be impaired. |
| Databáze: | OpenAIRE |
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