Serum S100A8/A9 as a Potentially Sensitive Biomarker for Inflammatory Bowel Disease
| Autor: | Makoto Okabe, Masaki Ikemoto, Hiroshi Itoh, Yuto Kimura, Kohki Okada |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Serum 0301 basic medicine medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity Inflammatory bowel disease Gastroenterology S100A8 Proinflammatory cytokine Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Calgranulin B Humans Medicine Calgranulin A Clinical significance Aged biology Diagnostic Tests Routine business.industry Biochemistry (medical) C-reactive protein Middle Aged Inflammatory Bowel Diseases medicine.disease Ulcerative colitis digestive system diseases 030104 developmental biology Cytokine 030220 oncology & carcinogenesis biology.protein Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Laboratory Medicine. 50:370-380 |
| ISSN: | 1943-7730 0007-5027 |
| DOI: | 10.1093/labmed/lmz003 |
| Popis: | Background The clinical significance of human S100A8/A9 (h-S100A8/A9) in patients with inflammatory bowel disease (IBD) is poorly understood. Objective To clarify whether serum S100A8/A9 is a sensitive biomarker for IBD. Methods Serum specimens from outpatients with IBD (n = 101) and healthy volunteers (HVs) (n = 101) were used in this study. Enzyme-linked immunosorbent assays for h-S100A8/A9 and inflammatory cytokines were performed using these specimens. Further, correlation analysis was performed to investigate the significance of h-S100A8/A9 fluctuation in patients with IBD. Results The average of serum h-S100A8/A9 concentration in outpatients with IBD was significantly higher than that in HVs. The concentration of h-S100A8/A9 in patients with IBD was barely correlated with that of CRP and inflammatory cytokines. Despite that finding, the serum level of h-S100A8/A9 in patients with ulcerative colitis (UC) was correlated with the severity of IBD, compared with other inflammatory proteins. Conclusion Serum h-S100A8/A9 is superior to CRP as a sensitive biomarker for IBD. |
| Databáze: | OpenAIRE |
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