Transcranial Direct Current Stimulation (tDCS) for major depression - Interim analysis of cloud supervised technical data from the DepressionDC trial
| Autor: | Alkomiet Hasan, S. Berkes, Peter Zwanzger, Berthold Langguth, Christian Plewnia, Daniel Keeser, Malek Bajbouj, Claus Normann, Silvia Egert-Schwender, Ulrike Kumpf, U. Palm, K. Schellhorn, Frank Padberg, M. Stadler |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Blinding medicine.medical_treatment Biophysics Prefrontal Cortex Cloud computing Neurosciences. Biological psychiatry. Neuropsychiatry Transcranial Direct Current Stimulation law.invention Physical medicine and rehabilitation Randomized controlled trial law medicine Electric Impedance Humans ddc:610 Depressive Disorder Major Transcranial direct-current stimulation business.industry Depression General Neuroscience medicine.disease Interim analysis ddc Treatment Outcome Data cloud Major depressive disorder Neurology (clinical) business RC321-571 |
| Zdroj: | Brain Stimulation, Vol 14, Iss 5, Pp 1234-1237 (2021) |
| ISSN: | 1876-4754 |
| Popis: | Background Transcranial direct current stimulation (tDCS) of prefrontal cortex regions has been reported to exert antidepressant effects, though large scale multicenter trials in major depressive disorder (MDD) supporting this notion are still lacking. Application of tDCS in multicenter settings, however, requires measurement, storage and evaluation of technical parameters of tDCS sessions not only for safety reasons but also for quality control. To address this issue, we conducted an interim analysis of supervised technical data across study centers in order to monitor technical quality of tDCS in an ongoing multicenter RCT in MDD (DepressionDC trial). Methods Technical data of 818 active tDCS sessions were recorded, stored in a data cloud, and analysed without violating study blinding. Impedance, voltage and current were monitored continuously with one data point recorded every second of stimulation. Results Variability of impedance was considerable (1,42 kΩ, to 8,23 kΩ), inter-individually and even more intra-individually, but did not significantly differ between the study centre in Munich and all other sites. Conclusion Measurement, centralized data storage via data cloud and remote supervision of technical parameters of tDCS are feasible and proposed for future RCTs on therapeutic tDCS in multiple settings. |
| Databáze: | OpenAIRE |
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