Nafcillin-induced platelet dysfunction and bleeding
| Autor: | Gerald Rothstein, M E Russo, D E Fohrman, David Alexander |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adolescent
Platelet Aggregation Platelet dysfunction medicine.drug_class Antibiotics Hemorrhage Nafcillin polycyclic compounds Humans Medicine Pharmacology (medical) Platelet Mean platelet volume Aged Pharmacology Bleeding episodes business.industry Abnormal bleeding biochemical phenomena metabolism and nutrition Infectious Diseases Epinephrine Anesthesia Female Blood Platelet Disorders business Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 23:59-62 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.23.1.59 |
| Popis: | This paper describes two cases of nafcillin-induced platelet dysfunction, with positive rechallenge data for one patient. Nafcillin resulted in abnormal bleeding times in both patients and a clinically apparent bleeding episode in one of the cases. Platelet function tests were performed on one patient during the initial therapy and after rechallenge with nafcillin. Platelet aggregation showed abnormal responses to ADP, collagen, and epinephrine. Platelet count and morphology were normal. Nafcillin should be recognized as another antibiotic which causes platelet function abnormalities and clinical bleeding episodes. |
| Databáze: | OpenAIRE |
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