Prognostic value of microRNA-126 and CRK expression in gastric cancer
| Autor: | Huichang Shi, Tiecheng Zhang, Dahong Zhang, Wei-guo Zhu, Jun Han, Shun Yue |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty animal structures Biology OncoTargets and Therapy 03 medical and health sciences Adapter molecule crk 0302 clinical medicine Internal medicine microRNA medicine Pharmacology (medical) Original Research Messenger RNA Oncogene Cancer miR-126 medicine.disease Reverse transcription polymerase chain reaction 030104 developmental biology 030220 oncology & carcinogenesis Cancer cell embryonic structures Sarcoma prognosis v-crk sarcoma virus CT10 oncogene homologue real-time quantitative polymerase chain reaction |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | Shun Yue,1,* Huichang Shi,2,* Jun Han,3 Tiecheng Zhang,1 Weiguo Zhu,1 Dahong Zhang1 1Department of Medical Oncology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an City, 2Department of Medical Oncology, The Second People’s Hospital of Huai’an, Huai’an City, 3Department of Medical Oncology, Qinghai Province People’s Hospital, Xining City, People’s Republic of China *These authors contributed equally to this work Background: MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer.Methods: miR-126 and CRK mRNA expression levels were detected by real-time quantitative reverse transcription polymerase chain reaction in 220 self-pairs of gastric cancer and adjacent noncancerous tissues.Results: Expression levels of miR-126 and CRK mRNA in gastric cancer tissues were, respectively, lower and higher than those in adjacent noncancerous tissues (both P |
| Databáze: | OpenAIRE |
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