Real-World Evidence Shows Clinicians Appropriately Use the Prognostic 40-Gene Expression Profile (40-GEP) Test for High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) Patients

Autor:	Perry B. Hooper, Aaron S. Farberg, Alison L. Fitzgerald, Jennifer J. Siegel, Briana B. Rackley, Anesh Prasai, Sarah J. Kurley, Matthew S. Goldberg, Graham H. Litchman
Rok vydání:	2022
Předmět:	Cancer Research Skin Neoplasms Oncology Carcinoma Squamous Cell Humans General Medicine Prognosis Transcriptome Neoplasm Staging
Zdroj:	Cancer Investigation. 40:911-922
ISSN:	1532-4192 0735-7907
Popis:	Treatment decisions for patients with cutaneous squamous cell carcinoma (cSCC) are traditionally based upon clinicopathologic risk factors and staging systems. Due to the accuracy limitations of these resources in predicting poor outcomes, there is a clinically significant need for more accurate methods of risk assessment. The 40-gene expression profile (40-GEP) test was developed to augment metastatic risk prediction of high-risk cSCC patients and has been validated in two independent, multi-center studies involving over 1,000 patients. This study substantiates that the 40-GEP is appropriately utilized by clinicians and that the personalized risk-stratification results are impactful in guiding risk-aligned patient management.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1a8fe2a23ffba0fae4c4a4e5cacfdb https://doi.org/10.1080/07357907.2022.2116454 Zobrazit plný text záznamu