Determinants of visfatin in type 2 diabetes patients with diabetic kidney disease: Relationship to inflammation, adiposity and undercarboxylated osteocalcin

Autor:	Alex C Kacso, Cosmina Ioana Bondor, Anca Laura Coman, Carmen Emanuela Georgescu, Alina Potra
Rok vydání:	2016
Předmět:	0301 basic medicine Male medicine.medical_specialty Clinical Biochemistry Osteocalcin Adipokine Renal function 030209 endocrinology & metabolism Type 2 diabetes Bone remodeling 03 medical and health sciences 0302 clinical medicine Skin fold Internal medicine Medicine Humans Diabetic Nephropathies Nicotinamide Phosphoribosyltransferase Adiposity Aged biology business.industry C-reactive protein General Medicine Middle Aged medicine.disease 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 Case-Control Studies biology.protein Albuminuria Cytokines Female medicine.symptom business Kidney disease Glomerular Filtration Rate
Zdroj:	Scandinavian journal of clinical and laboratory investigation. 76(3)
ISSN:	1502-7686
Popis:	Visfatin is a proinflammatory molecule with possible actions on glucose metabolism. Interactions to bone metabolism and undercarboxylated osteocalcin (uOC) in diabetic patients (T2DP) with diabetic kidney disease (DKD) have not been reported.We included 51 incident T2DP with DKD. History, laboratory evaluation, anthropometry, visfatin, uOC were obtained. Fifteen T2DP without DKD were used as controls.Visfatin was similar in DKD patients and controls: 1.56(0.97-3.03) versus 2.04(1.08-3.21) ng/mL, p = 0.51. In controls, visfatin positively correlated with diabetes duration (r = 0.63, p = 0.01) and negatively with uOC (r = -0.57, p = 0.03). In multivariate regression, diabetes duration remained significant (p = 0.01). In patients with DKD, visfatin was positively linked to C reactive protein (r = 0.27, p = 0.05), tricipital skin fold (TSF) (r = 0.41, p = 0.004) and leukocytes (r = 0.37, p = 0.01); the latter two parameters predicted visfatin in multivariate model (p = 0.001). In normoalbuminuric patients, visfatin was linked to body mass index (r = 0.32, p = 0.04), waist circumference (r = 0.42, p 0.0001), LDL cholesterol (r = 0.33, p = 0.03), serum glucose (r = 0.36, p = 0.03) and glycated hemoglobin (r = 0.41, p = 0.007); there was a trend towards negative correlation to uOC (r = -0.28, p = 0.07); only glycaemia remained significant in multivariate analysis (p = 0.04). Albuminuric patients displayed a positive correlation of visfatin to waist to hip ratio (r = 0.41, p = 0.04) and leukocytes (r = 0.56, p = 0.04); the latter remained significant in multivariate regression (p = 0.005).The main determinant of visfatin in T2D patients with DKD is inflammation; in normoalbuminuric patients, a positive link to adiposity and altered glycemic control and a trend towards a negative correlation to uOC was observable; the latter relationship was evident in patients without DKD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1a0bbc42dbe6a0e3dce70af2267603 https://pubmed.ncbi.nlm.nih.gov/26922969 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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