Does nebivolol have renoprotective action in patients with chronic kidney disease conditions? An integrative review
| Autor: | Katharyna Cardoso de Gois, Carlos Henrique Foncesca Peiró, Matheus Moreira Perez, Beatriz da Costa Aguiar Alves, Diogo Pimenta Simões, Neif Murad, Fernando Luiz Affonso Fonseca, Jéssica Freitas Araújo Encinas, Joyce Regina Santos Raimundo, Catherine Giovanna Costas Arcia, Patricia Ferrante Draghi, Glaucia Luciano da Veiga, Marina Cristina Peres |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Agonist medicine.drug_class Pharmacology Protective Agents Nebivolol 03 medical and health sciences 0302 clinical medicine medicine Animals Humans In patient cardiovascular diseases Renal Insufficiency Chronic Receptor Kidney business.industry Antagonist medicine.disease 030104 developmental biology medicine.anatomical_structure Receptors Adrenergic beta-3 Hypertension Adrenergic beta-3 Receptor Antagonists Menopause business 030217 neurology & neurosurgery Mace medicine.drug Kidney disease |
| Zdroj: | European Journal of Pharmacology. 905:174180 |
| ISSN: | 0014-2999 |
| Popis: | Systemic arterial hypertension (SAH) is a chronic disease of multifactorial origin and one of the main risk factors for major adverse cardiovascular events (MACE), which are the leading causes of morbidity and mortality worldwide. The pharmacological treatment of SAH involves five main classes of drugs, and Nebivolol (NEB) is one of those drugs, belonging to the class of third generation β1-adrenoceptors selective blockers. NEB is composed of a racemic mixture of two enantiomers: d-nebivolol, which exerts antagonist effects on β1-adrenoceptors, and l-nebivolol, a vascular β3 receptor agonist. There are several studies that report different actions of NEB, not only for the treatment of SAH, but also as an antioxidant agent or even as a protector of renal damage. The aim of this systematic review was to investigate the available evidence regarding the effects of NEB on kidney diseases, evaluating its possible renoprotective action. |
| Databáze: | OpenAIRE |
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