Species-specific temperature sensitivity of TRPA1
| Autor: | Willem J. Laursen, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Evan O. Anderson, Lydia J. Hoffstaetter |
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| Rok vydání: | 2014 |
| Předmět: |
hsTRPA1- hymenoptera-specific TRPA1
Temperature sensitivity Physiology TRPA1- transient receptor potential ankyrin 1 AITC- allyl isothiocyanate Thermosensation Gating Review TRPA1 ANKTM1- ankyrin-like with transmembrane domains protein 1 Transient receptor potential channel Chemical stimuli ΔCp -change in heat capacity ANKTM1 TRPV1- transient receptor potential vanilloid 1 EC50- half maximal effective concentration Physiology (medical) ThermoTRP Ankyrin ceTRPA1- Caenorhabditis elegans TRPA1 Sensitivity (control systems) PH- pore helix Ion channel S1-S6- transmembrane helices 1–6 chemistry.chemical_classification PI- phosphatidylinositol Chemistry AR- ankyrin repeat food and beverages Chemical sensitivity Biochemistry Keq- equillibrium constant Q10- temperature activation coefficient Ion channels TRPM8- transient receptor potential melastatin 8 Biological system psychological phenomena and processes dTRPA1- Drosophila melanogaster TRPA1 TRP- Transient Receptor Potential |
| Zdroj: | Temperature: Multidisciplinary Biomedical Journal |
| ISSN: | 2332-8940 |
| Popis: | Transient receptor potential ankyrin 1 (TRPA1) is a polymodal ion channel sensitive to temperature and chemical stimuli. The importance of temperature and aversive chemical detection for survival has driven the evolutionary diversity of TRPA1 sensitivity. This diversity can be observed in the various roles of TRPA1 in different species, where it is proposed to act as a temperature-insensitive chemosensor, a heat transducer, a noxious cold transducer, or a detector of low-intensity heat for prey localization. Exploring the variation of TRPA1 functions among species provides evolutionary insight into molecular mechanisms that fine-tune thermal and chemical sensitivity, and offers an opportunity to address basic principles of temperature gating in ion channels. A decade of research has yielded a number of hypotheses describing physiological roles of TRPA1, modulators of its activity, and biophysical principles of gating. This review surveys the diversity of TRPA1 adaptations across evolutionary taxa and explores possible mechanisms of TRPA1 activation. |
| Databáze: | OpenAIRE |
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