Role of N-methyl-d-aspartate receptor in acute spinal cord injury
| Autor: | Mitsuhiro Yanase, Takeo Fukuda, Takashi Sakou |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Blood Pressure Vascular permeability Receptors N-Methyl-D-Aspartate Spinal Cord Diseases Capillary Permeability Central nervous system disease Internal medicine Edema medicine Animals Receptor Spinal cord injury Spinal Cord Injuries business.industry Microcirculation Glutamate receptor Spinal cord medicine.disease medicine.anatomical_structure Endocrinology Spinal Cord Regional Blood Flow Anesthesia Acute Disease NMDA receptor Rabbits Dizocilpine Maleate medicine.symptom business Excitatory Amino Acid Antagonists |
| Zdroj: | Journal of Neurosurgery. 83:884-888 |
| ISSN: | 0022-3085 |
| DOI: | 10.3171/jns.1995.83.5.0884 |
| Popis: | ✓ To clarify the role of N-methyl-d-aspartate (NMDA) receptors in acute spinal cord injury, changes in the intraspinal microcirculation after acute spinal cord injury in rabbits were examined. Systemic administration of MK-801, an NMDA receptor antagonist, at a dose of 5 mg/kg, significantly improved motor recovery after injury and significantly reduced edema formation at the injured site without altering spinal cord blood flow or vascular permeability at the injured site. These findings indicate that excitatory amino acids contribute to secondary spinal cord damage, especially edema formation, mediated by NMDA receptors in the early stage after injury. |
| Databáze: | OpenAIRE |
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