Modernized low pressure carbonylation methods in batch and flow employing common acids as a CO source
| Autor: | Célia Brancour, Ilhyong Ryu, Takahide Fukuyama, Troels Skrydstrup, Yu Mukai |
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| Rok vydání: | 2013 |
| Předmět: |
Carbon Monoxide
Formates Formic acid Aryl Organic Chemistry Sonogashira coupling Sulfuric acid Sulfuric Acids Biochemistry Koch reaction chemistry.chemical_compound chemistry Ethylamines Pressure Organic chemistry Physical and Theoretical Chemistry Carbonylation Triethylamine Polytetrafluoroethylene Carbon monoxide |
| Zdroj: | Brancour, C, Fukuyama, T, Mukai, Y, Skrydstrup, T & Ryu, I 2013, ' Modernized low pressure carbonylation methods in batch and flow employing common acids as a CO source ', Organic Letters, vol. 15, no. 11, pp. 2794-2797 . https://doi.org/10.1021/ol401092a |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/ol401092a |
| Popis: | Carbonylation reactions, such as Heck, Sonogashira, and radical carbonylations, were successfully carried out in a "two-chamber reactor" where carbon monoxide was produced ex situ by the Morgan reaction (dehydration of formic acid by sulfuric acid). By a subsequent application in a microflow system using a "tube-in-tube" reactor where gas-permeable Teflon AF2400 was used as the inner tube, it is demonstrated that formic acid/sulfuric acid can be employed concomitantly with an amine base such as triethylamine in the Heck aminocarbonylation of aryl iodide. |
| Databáze: | OpenAIRE |
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