Gut mucosa in the rats exposed temporary mechanical obstruction fed with probiotic
| Autor: | Cigdem Yenisey, Ibrahim Meteoglu, Eyüp Murat Yılmaz, Akay Edizsoy, Serhan Sakarya, Mehmet Hakan Çevikel |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Glutathione reductase Administration Oral Spleen Gastroenterology law.invention Probiotic law Ileum Internal medicine medicine Terminal ileum Animals In patient Intestinal Mucosa Rats Wistar Lymph node biology business.industry Probiotics Cell loss Rats Disease Models Animal Anesthesiology and Pain Medicine medicine.anatomical_structure Liver Catalase Bacterial Translocation Emergency Medicine biology.protein Surgery Female business Intestinal Obstruction |
| Zdroj: | Ulusal travma ve acil cerrahi dergisi = Turkish journal of traumaemergency surgery : TJTES. 26(6) |
| ISSN: | 1306-696X |
| Popis: | BACKGROUND Created a model in the rats, to prevent mucosal damage and related effects in the patients, who were operated due to mechanical obstruction. Some groups fed fodder with probiotics, some groups fed with standard fodder. It is objected that the damage of gut mucosa and related effects on how to expose the differences of the groups. METHODS In this study, 48 female Wistar-albino type rats are separated into five groups randomly. In the first operation, rats' terminal ileum was tied up with silk except for the control group. Two groups 24, the other two groups 48 hours later operated again and terminal ileum obstructions were removed. During that time, each one of those 24 and 48 hours of obstructed groups were fed with probiotic. Twenty-four hours later, the control group and other groups were operated for the third time for sampling. Terminal ileum, liver, spleen, MLN (Mesenteric lymph node) and blood samples were taken. RESULTS The research group, which was obstructed and fed with probiotics during 48 hours, was significantly observed in increased mucosa cell loss and mucosal edema. Bacterial translocation was found more common in groups without probiotics. Tissue GR (Glutathione reductase) and erythrocyte CAT (Catalase) were lower in the group of 24 hours obstructed and given probiotics. CONCLUSION The findings suggest that the high rate of mucosal edemas in the groups that are fed with probiotics can be seen as damage, but we think that probiotics are consonant with the strength of the mucosal barrier. Thus, in the groups fed with probiotics, it is possible that bacterial translocation is seen less, and some antioxidative enzymes are found less. Further studies are needed to investigate the benefits of probiotics in patients operated for obstruction. |
| Databáze: | OpenAIRE |
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