Effect of metergoline on serum prolactin stimulated by TRH
| Autor: | C. Pollini, G. Gadaleta, F. Iannotta, M. P. Vettaro |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Drug endocrine system medicine.medical_specialty Metergoline endocrine system diseases Endocrinology Diabetes and Metabolism media_common.quotation_subject Central nervous system Thyrotropin-releasing hormone Pharmacology Serum prolactin chemistry.chemical_compound Endocrinology Internal medicine medicine Humans Ergolines Thyrotropin-Releasing Hormone media_common business.industry Significant difference Healthy subjects Prolactin medicine.anatomical_structure chemistry Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Endocrinological Investigation. 3:301-303 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03348280 |
| Popis: | The PRL response to TRH was evaluated before and after acute administration of metergoline, an antiserotonin drug, in healthy subjects. The drug was given to two groups of 6 subjects each, at the dose of 4 and 8 mg respectively, either po or by im route. Metergoline significantly inhibited the PRL response to TRH; no significant difference was found between the two doses and the administration routes. Although these findings suggest that the drug may directly inhibit lactotropic cells, an action of metergoline on central nervous system to stimulate PIF or to inhibit PRF release cannot be ruled out, and might as well explain the inhibition of the PRL response to TRH. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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