Preoperative γ-glutamyl transpeptidase to platelet ratio (GPR) is an independent prognostic factor for HBV-related hepatocellular carcinoma after curative hepatic resection
| Autor: | Xing-Long Zheng, Zhi-Yong Zhang, Ying Zhou, Zheng Wu, Wanli Wang, Bo Wang, Gang Tang, Ou Li, Jun-Xi Xiang, Jie Hao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Liver Cirrhosis
Male Pathology Cirrhosis GPR medicine.medical_treatment medicine.disease_cause Gastroenterology 0302 clinical medicine Medicine HCC Liver Neoplasms General Medicine gamma-Glutamyltransferase hepatocellular carcinoma Hepatitis B Middle Aged Prognosis Treatment Outcome 030220 oncology & carcinogenesis Hepatocellular carcinoma Preoperative Period 030211 gastroenterology & hepatology Female Research Article medicine.medical_specialty Carcinoma Hepatocellular Observational Study 03 medical and health sciences Internal medicine Carcinoma Biomarkers Tumor Hepatectomy Humans Propensity Score Survival analysis Tumor marker Retrospective Studies Hepatitis B virus γ-glutamyl transpeptidase to platelet ratio business.industry Platelet Count fungi medicine.disease Survival Analysis digestive system diseases Neoplasm Recurrence Local business |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Liver fibrosis and cirrhosis is associated with the prognosis of patients with hepatocellular carcinoma (HCC) after treatment. The γ-glutamyl transpeptidase to platelet ratio (GPR) is reported to predict significant liver fibrosis and cirrhosis. The aim of this study was to investigate the predictive value of preoperative GPR on the recurrence and survival of patients with HCC who underwent curative hepatectomy. A retrospective review of demographics, medical records, and prognosis of patients with hepatitis B virus (HBV)–related HCC was performed. Overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan–Meier method, and the log-rank test was used to analyze differences in recurrence and survival. Univariate and multivariate analyses were used for significance of prognostic factor. A total of 357 patients with HBV-related HCC were included in this analysis. The preoperative GPR was associated with recurrence and survival rates, independent of HCC progression or tumor marker levels, in a multivariate analysis. OS was higher in patients with a GPR |
| Databáze: | OpenAIRE |
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