Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages
| Autor: | Lindsey Castoldi, Andréa Vanessa Ferreira da Silva Pinto, Priscila Raquel Martins, Graziela Gorete Romagnoli, Maria Carolina Gameiro, Ramon Kaneno, Fabiane Catanho Lopes, Wagner Loyola |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade Bandeirantes (UNIBAN) |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Male lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Phagocytosis Agaricus lcsh:QR1-502 Mannose Stimulation Receptors Cell Surface Nitric Oxide lcsh:Microbiology Microbiology Nitric oxide chemistry.chemical_compound Mice Polysaccharides Candida albicans mushroom Animals Lectins C-Type Receptor Mice Inbred BALB C biology fungi Hydrogen Peroxide microbicidal activity biology.organism_classification Corpus albicans Mannose-Binding Lectins chemistry Macrophages Peritoneal Mannose receptor Mannose Receptor |
| Zdroj: | Memórias do Instituto Oswaldo Cruz., Vol 103, Iss 3, Pp 244-250 (2008) Memórias do Instituto Oswaldo Cruz, Volume: 103, Issue: 3, Pages: 244-250, Published: 30 APR 2008 SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1678-8060 0074-0276 |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:45:35Z No. of bitstreams: 1 S0074-02762008000300003.pdf: 759577 bytes, checksum: cd8157157dc324822e82a351b915c6d2 (MD5) Made available in DSpace on 2013-08-22T18:45:35Z (GMT). No. of bitstreams: 1 S0074-02762008000300003.pdf: 759577 bytes, checksum: cd8157157dc324822e82a351b915c6d2 (MD5) Previous issue date: 2008-05-01 Made available in DSpace on 2013-09-30T19:34:41Z (GMT). No. of bitstreams: 2 S0074-02762008000300003.pdf: 759577 bytes, checksum: cd8157157dc324822e82a351b915c6d2 (MD5) S0074-02762008000300003.pdf.txt: 39528 bytes, checksum: 2bc168db657013ddd28e713c3e63813e (MD5) Previous issue date: 2008-05-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:50:48Z No. of bitstreams: 2 S0074-02762008000300003.pdf: 759577 bytes, checksum: cd8157157dc324822e82a351b915c6d2 (MD5) S0074-02762008000300003.pdf.txt: 39528 bytes, checksum: 2bc168db657013ddd28e713c3e63813e (MD5) Made available in DSpace on 2014-05-20T13:50:48Z (GMT). No. of bitstreams: 2 S0074-02762008000300003.pdf: 759577 bytes, checksum: cd8157157dc324822e82a351b915c6d2 (MD5) S0074-02762008000300003.pdf.txt: 39528 bytes, checksum: 2bc168db657013ddd28e713c3e63813e (MD5) Previous issue date: 2008-05-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after 48 h their peritoneal resident macrophages were assayed against Candida albicans yeast forms. The treatment increased fungicidal activity and it was associated with higher levels of H2O2, whereas NO production was not affected. We also found that the treatment enhances mannose receptor expression by peritoneal macrophages, which are involved in the attachment and phagocytosis of non-opsonized microorganisms. Treatment of animals with ATF was able to enhance the clearance of C. albicans during the first 6 h after the experimental i.p. infection. Our results suggest that this extract can increase host resistance against some infectious agents through the stimulation of microbicidal activity of macrophages. Universidade Estadual Paulista Instituto de Biociências Departamento de Microbiologia e Imunologia UNESP Faculdade de Medicina Departamento de Patologia UNESP Faculdade de Medicina Departamento de Doenças Tropicais e Diagnóstico por Imagem Universidade Bandeirantes Universidade Estadual Paulista Instituto de Biociências Departamento de Microbiologia e Imunologia UNESP Faculdade de Medicina Departamento de Patologia UNESP Faculdade de Medicina Departamento de Doenças Tropicais e Diagnóstico por Imagem FAPESP: 98/07726-5R |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|