Increased cyclic guanosine monophosphate production and endothelial nitric oxide synthase level in mononuclear cells from sildenafil citrate-treated patients with erectile dysfunction
| Autor: | Antonio J. López-Farré, R Vela, Carlos Macaya, Javier Modrego, E Mahillo, J Garcia-Cardoso, Petra J. Mateos-Cáceres |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Nitric Oxide Synthase Type III medicine.drug_mechanism_of_action Phosphodiesterase Inhibitors Sildenafil Urology Guanosine Monophosphate Peripheral blood mononuclear cell Monocytes Piperazines Sildenafil Citrate Body Mass Index Impotence Vasculogenic chemistry.chemical_compound Erectile Dysfunction Internal medicine medicine Humans Sulfones Phosphodiesterase inhibitor Cyclic guanosine monophosphate Aged Cyclic Nucleotide Phosphodiesterases Type 5 Glycated Hemoglobin biology business.industry Middle Aged Intercellular Adhesion Molecule-1 PDE5 drug design respiratory tract diseases Nitric oxide synthase C-Reactive Protein Cholesterol Endocrinology chemistry Guanylate Cyclase Purines Enzyme inhibitor cardiovascular system biology.protein business Phosphodiesterase 5 inhibitor |
| Zdroj: | International Journal of Impotence Research. 22:68-76 |
| ISSN: | 1476-5489 0955-9930 |
| DOI: | 10.1038/ijir.2009.51 |
| Popis: | Mononuclear cells express enzymes involved in the NO/cyclic guanosine monophosphate (cGMP) generating system, as well as PDE5. The objective of the study was to determine the effect of sildenafil citrate administration on the level of proteins involved in the NO/cGMP generating system in mononuclear cells from patients with ED. Twenty-one patients with ED (International Index of Erectile Function-Erectile Function Domain (IIEF-EFD) 17.9+/-0.8) were enrolled and 100 mg sildenafil citrate on-demand was administered during 12 weeks. All patients showed cardiovascular risk factors. After sildenafil citrate administration, IIEF-EFD score was improved (26+/-1.2 P |
| Databáze: | OpenAIRE |
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