Tolerance of hemodialysis: a randomized prospective trial of high-flux versus conventional high-efficiency hemodialysis
| Autor: | Steve J. Schwab, M Oliverio, J S Tannenbaum, M B Lambert, D M Collins |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Vomiting medicine.medical_treatment Acrylic Resins Biocompatible Materials Hematocrit Angina Renal Dialysis medicine Ethnicity Humans Prospective Studies Cellulose Saline Dialysis Muscle Cramp medicine.diagnostic_test Acrylonitrile business.industry Cuprophane Membranes Artificial General Medicine Middle Aged medicine.disease Crossover study Blood Cell Count Blood pressure Treatment Outcome Nephrology Anesthesia Female Hemodialysis Hypotension business |
| Zdroj: | Journal of the American Society of Nephrology : JASN. 4(2) |
| ISSN: | 1046-6673 |
| Popis: | Hemodialysis is frequently complicated by hypotension and associated symptoms. It has been suggested that these symptoms may be related to the biochemical changes caused by cellulosic dialysis membranes. In this study, a prospective randomized crossover trial was conducted comparing the incidence of hypotension and acute symptoms during dialysis with large-surface-area (1.6 m2) cellulosic (cuprophane [CUP]) and noncellulosic (polyacrylonitrile [PAN], AN69) membranes. Dialyzers were used for a single use only. There was no difference in predialysis BUN, predialysis blood pressure, intradialytic weight gain, blood flow, dialysis efficiency (urea reduction), dialysis duration, hematocrit, or erythropoietin dose between the two study phases. When these clinical characteristics were matched, there was no difference in the number of episodes of hypotension (CUP, 19 +/- 3; PAN, 22 +/- 3; P = not significant [NS]). The incidence of symptomatic hypotension, as reflected by the number of episodes of hypotension requiring more than 100 mL of saline for correction, was also not different between study phases (CUP, 10 +/- 1; AN69, 11 +/- 2; P = NS). The incidence of intradialytic symptoms, including emesis, cramping, headache, angina, pruritus, and bronchospasm, was similar during the two study phases (CUP, 11 +/- 2; AN69, 10 +/- 1; P = NS). It was concluded that noncellulosic membranes do not offer any significant advantage over cellulosic membranes in reducing the acute complications of hemodialysis. |
| Databáze: | OpenAIRE |
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