Changes in the Proportion of Inhibitory Interneuron Types from Sensory to Executive Areas of the Primate Neocortex: Implications for the Origins of Working Memory Representations
| Autor: | Xiao Jing Wang, Wataru Inoue, Michelle Everest, Julio Martinez-Trujillo, Santiago Torres-Gomez, Michael O. Poulter, Diego Mendoza-Halliday, Eric S. Kuebler, Jackson D. Blonde |
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| Rok vydání: | 2020 |
| Předmět: |
Male
narrow and broad spiking middle temporal Cognitive Neuroscience Vasoactive intestinal peptide CR interneurons Sensory system Neocortex PV interneurons working memory (WM) Cellular and Molecular Neuroscience Interneurons biology.animal medicine Premovement neuronal activity Animals Primate Prefrontal cortex medial superior temporal prefrontal cortex biology Working memory Macaca mulatta medicine.anatomical_structure Memory Short-Term nervous system biology.protein Original Article Neuroscience inhibition-excitation balance Parvalbumin |
| Zdroj: | Cereb Cortex Physiology and Pharmacology Publications |
| ISSN: | 1460-2199 |
| Popis: | © 2020 The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com. Neuronal spiking activity encoding working memory (WM) is robust in primate association cortices but weak or absent in early sensory cortices. This may be linked to changes in the proportion of neuronal types across areas that influence circuits' ability to generate recurrent excitation. We recorded neuronal activity from areas middle temporal (MT), medial superior temporal (MST), and the lateral prefrontal cortex (LPFC) of monkeys performing a WM task and classified neurons as narrow (NS) and broad spiking (BS). The ratio NS/BS decreased from MT > MST > LPFC. We analyzed the Allen Institute database of ex vivo mice/human intracellular recordings to interpret our data. Our analysis suggests that NS neurons correspond to parvalbumin (PV) or somatostatin (SST) interneurons while BS neurons are pyramidal (P) cells or vasoactive intestinal peptide (VIP) interneurons. We labeled neurons in monkey tissue sections of MT/MST and LPFC and found that the proportion of PV in cortical layers 2/3 decreased, while the proportion of CR cells increased from MT/MST to LPFC. Assuming that primate CR/CB/PV cells perform similar computations as mice VIP/SST/PV cells, our results suggest that changes in the proportion of CR and PV neurons in layers 2/3 cells may favor the emergence of activity encoding WM in association areas. |
| Databáze: | OpenAIRE |
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