Role of angiogenic and non-angiogenic mechanisms in oral squamous cell carcinoma: correlation with histologic differentiation and tumor progression
| Autor: | Long-Chang Chang, Cheng-Wen Wu, Herng-Sheng Lee, Yi-Shing Shieh, Yi-Wen Chu, Shine-Gwo Shiah |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
CD31
Cancer Research Pathology medicine.medical_specialty Angiogenesis CD34 Antigens CD34 Pathology and Forensic Medicine Immunoenzyme Techniques Vascularity von Willebrand Factor medicine Humans Neoplasm Invasiveness Neoplasm Staging Analysis of Variance Chi-Square Distribution Neovascularization Pathologic business.industry Microcirculation Cancer medicine.disease Platelet Endothelial Cell Adhesion Molecule-1 stomatognathic diseases Otorhinolaryngology Epidermoid carcinoma Tumor progression cardiovascular system Carcinoma Squamous Cell Disease Progression Periodontics Immunohistochemistry Mouth Neoplasms Endothelium Vascular Oral Surgery medicine.symptom business |
| Zdroj: | Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 33(10) |
| ISSN: | 0904-2512 |
| Popis: | Background: Angiogenesis has been demonstrated to associate with various measures of tumor aggressiveness in many human malignancies. However, studies of tumor angiogenesis in oral squamous cell carcinoma (SCC) are still unclear. Recent studies indicate non-angiogenesis mechanism (tumor-lined vessel) may exist in certain tumors. Therefore, we investigate microvessel density (MVD) and tumor-lined vessel in oral SCC. Methods: Peritumoral and intratumoral MVD were measured by immunohistochemical staining. Tumor-lined vessels were identified by double staining. Statistical analysis of peritumoral and intratumoral MVD and presence of tumor-lined vessels with clinicopathologic parameters was performed. Results: The results showed peritumoral MVD increased with disease progression and further increases of intratumoral MVD was detected by CD31 and CD34. Non-angiogenesis, tumor-lined vessel, presented in oral SCC and correlated significantly with tumor size, stage, and histologic differentiation. Conclusion: Our results suggest at the initiation of oral SCC, increasing vascularity is observed at the periphery of the tumor. As the tumor continues to grow, further increases of intratumoral vascularity and the presence of tumor-lined vessels are associated with cancer progression. |
| Databáze: | OpenAIRE |
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