Comparing Symptomatic and Asymptomatic Carotid Artery Atherosclerosis in Patients With Bilateral Carotid Vulnerable Plaques Using Magnetic Resonance Imaging
| Autor: | Yingyu Miao, Cheng Li, Xihai Zhao, Ziwei Du, Chun Yuan, Rui-Jing Xin, Jin Li, Huimin Xu, Dandan Yang, Hualu Han, Rui Li, Rui Shen, Shasha Deng, Zihan Ning, Qian Ding |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Carotid arteries 030204 cardiovascular system & hematology medicine.disease_cause Asymptomatic 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans In patient Carotid Stenosis Thrombus Aged medicine.diagnostic_test business.industry Fibrous cap Magnetic resonance imaging Odds ratio Middle Aged medicine.disease Atherosclerosis Vulnerable plaque Magnetic Resonance Imaging Plaque Atherosclerotic medicine.anatomical_structure Carotid Arteries Cardiology medicine.symptom Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Angiology. 73(2) |
| ISSN: | 1940-1574 |
| Popis: | We compared plaque characteristics between symptomatic and asymptomatic sides in patients with bilateral carotid vulnerable plaques using magnetic resonance imaging (MRI). Participants (n = 67; mean age: 65.8 ± 7.7 years, 61 males) with bilateral carotid vulnerable plaques were included. Vulnerable plaques were characterized by intraplaque hemorrhage (IPH), large lipid-rich necrotic core (LRNC), or fibrous cap rupture (FCR) on MRI. Symptomatic vulnerable plaques showed greater plaque burden, LRNC volume (median: 221.4 vs 134.8 mm3, P = .003), IPH volume (median: 32.2 vs 22.5 mm3, P = .030), maximum percentage (Max%) LRNC (median: 51.3% vs 41.8%, P = .002), Max%IPH (median: 13.4% vs 9.5%, P = .022), cumulative slices of LRNC (median: 10 vs 8, P = .005), and more juxtaluminal IPH and/or thrombus (29.9% vs 6.0%, P = .001) and FCR (37.3% vs 16.4%, P = .007) than asymptomatic ones. After adjusting for plaque burden, differences in juxtaluminal IPH and/or thrombus (odds ratio [OR]: 5.49, 95% CI: 1.61-18.75, P = .007) and FCR (OR: 2.90, 95% CI: 1.16-7.24, P = .022) between bilateral sides remained statistically significant. For patients with bilateral carotid vulnerable plaques, symptomatic plaques had greater burden, more juxtaluminal IPH and/or thrombus, and FCR compared with asymptomatic ones. The differences in juxtaluminal IPH and/or thrombus and FCR between bilateral sides were independent of plaque burden. |
| Databáze: | OpenAIRE |
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