Nephro-urological complications of epidermolysis bullosa in paediatric patients
| Autor: | M.J. Dillon, P.G. Duffy, D.J. Atherton, S.M.H. Chan |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Urologic Diseases medicine.medical_specialty Adolescent medicine.medical_treatment Dermatology urologic and male genital diseases Peritoneal dialysis Nephropathy Biopsy Humans Medicine Renal Insufficiency Child Kidney medicine.diagnostic_test business.industry Glomerulonephritis medicine.disease Surgery Treatment Outcome medicine.anatomical_structure Child Preschool Female Renal biopsy Epidermolysis bullosa Epidermolysis Bullosa business Complication |
| Zdroj: | British Journal of Dermatology. 156:143-147 |
| ISSN: | 1365-2133 0007-0963 |
| Popis: | A small but important proportion of patients with epidermolysis bullosa (EB) may develop significant renal and urological complications which can have a major impact on their morbidity and mortality. During the last 10 years, five of a large group of children with EB under our care, with either dystrophic or junctional types of disease, experienced major nephro-urological complications. Two patients with recessive dystrophic EB (REDB) developed macroscopic haematuria - one had renal failure and underwent a renal biopsy showing IgA nephropathy. A third patient with RDEB also developed renal failure and his biopsy demonstrated postinfectious glomerulonephritis/type III membranoproliferative (mesangiocapillary) glomerulonephritis. Both patients with renal failure underwent peritoneal dialysis. Two patients with junctional EB developed obstructive uropathies, which required bladder reconstruction and the fashioning of a Mitrofanoff channel in one. |
| Databáze: | OpenAIRE |
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