Lysyl oxidase like protein-2 (LOXL-2); a novel marker for prediction of intrahepatic cholestasis of pregnancy
| Autor: | Banuhan Şahin, Uğur Turhan, Ismail Dag |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Cholestasis Intrahepatic Bile Acids and Salts Protein-Lysine 6-Oxidase 03 medical and health sciences 0302 clinical medicine Cholestasis Pregnancy Internal medicine medicine Humans chemistry.chemical_classification 030219 obstetrics & reproductive medicine Bile acid Bile duct business.industry Obstetrics and Gynecology medicine.disease Pregnancy Complications Cross-Sectional Studies medicine.anatomical_structure Endocrinology Enzyme chemistry Case-Control Studies Pediatrics Perinatology and Child Health Female 030211 gastroenterology & hepatology Amino Acid Oxidoreductases Hepatic fibrosis business Cholestasis of pregnancy Lysyl Oxidase-Like Protein 2 |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 34:2363-2368 |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | Lysyl oxidase like protein 2 (LOXL-2) is an enzyme that is involved in the development of hepatic fibrosis and bile duct epithelial injury in hepatic cholestasis. Our aim was to investigate maternal serum levels of LOXL-2 and their relationship with fasting total bile acid (FTBA) levels in patients with intrahepatic cholestasis of pregnancy (ICP).Thirty-five pregnant women with ICP and 35 healthy women with uncomplicated pregnancies as the control group, were included in this cross-sectional study. Maternal serum LOXL-2, FTBA and other liver function test levels were compared between the two groups. The predictive cutoff value for LOXL-2 level in ICP was specified.Serum LOXL-2 levels were found to be higher in the ICP group compared to the control group (225.699 ± 142.453 vs. 127.731 ± 63.419 pg/mL,Maternal serum LOXL-2 levels were significantly higher in women with ICP. LOXL-2 may be both an initiating factor in the pathophysiology of ICP and a marker in the prediction. It may also be a target in terms of preventing strategies in ICP. |
| Databáze: | OpenAIRE |
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