Hemostatic profile in healthy premature neonates; Does birth weight affect the coagulation profile?
| Autor: | Behnaz Mahdaviani, Nima Hafezi-Nejad, Sara Sheikhbahaei, Alireza Abdollahi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pediatrics medicine.diagnostic_test biology Obstetrics business.industry Birth weight prematurity Gestational age Context (language use) Fibrinogen Protein S Coagulation Pediatrics Perinatology and Child Health medicine biology.protein Original Article coagulation neonate business Protein C circulatory and respiratory physiology Partial thromboplastin time medicine.drug |
| Zdroj: | Journal of Clinical Neonatology |
| ISSN: | 2249-4847 |
| Popis: | Context: There are limited studies assessing the neonatal hemostatic factors in relation to birth weight. Aims: This study aims to compare the coagulation factors between three groups of neonates with different birth weight for gestational age (GA). Settings and Design: In a cross-sectional study, 74 healthy premature neonates were involved. Subjects and Methods: Serum prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), thrombin clotting time (TT), and levels of fibrinogen, anti-thrombin III, protein S and protein C were measured. Neonates were classified into three groups according to birth weight, including small, appropriate and large for gestational age (SGA, AGA, and LGA). Statistical Analysis Used: Statistical analysis was performed using SPSS software. Results: There was a significant difference in the levels of protein S (P < 0.001), protein C (P = 0.004), and values of APTT (P = 0.01) between three groups. Other coagulation factors however, did not represent a significant pattern (P > 0.05). Protein S concentration, directly (B = 0.78, P < 0.001), and APTT, inversely (B = −0.29, P = 0.03), associated with birth weight after adjustment for GA and sex. Conclusions: Despite the decrease in APTT from SGA to AGA, and LGA neonates, levels of protein S increases directly with birth weight. However, no other coagulation factors revealed an explainable pattern in relation to the state of SGA, AGA, or LGA. |
| Databáze: | OpenAIRE |
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