Utilization of supercritical carbon dioxide for development of antibacterial surgical sutures
| Autor: | Petar S. Uskoković, Jelena Pajnik, Suzana Dimitrijević-Branković, Dušica B. Stojanović, Ivona Janković-Častvan, Stoja Milovanovic |
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| Rok vydání: | 2022 |
| Předmět: |
Surgical suture
Supercritical carbon dioxide Chemistry General Chemical Engineering Natural compound Impregnation 02 engineering and technology Supercritical CO2 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Thymol Supercritical fluid 0104 chemical sciences Solvent chemistry.chemical_compound Antibacterial activity Physical and Theoretical Chemistry 0210 nano-technology Surgical Infections Nuclear chemistry |
| Zdroj: | Journal of Supercritical Fluids |
| ISSN: | 0896-8446 |
| DOI: | 10.1016/j.supflu.2021.105490 |
| Popis: | Outbreak of surgical infections and bacterial resistance against synthetic antibiotic has prompted research towards development of antibacterial medical devices. For that purpose, absorbable surgical sutures were impregnated with natural compound thymol using an environmentally friendly medium. The supercritical solvent impregnation process was performed at 35 degrees C and 10 MPa during 1, 2, 3 and 6 h, resulting in thymol loadings of 3.9-5.6%. All tested samples expressed antibacterial activity against E. coli and S. aureus. Release tests in PBS at 37 degrees C showed that impregnated material released loaded thymol in a gradual manner. While sutures impregnated during 6 h released complete amount of loaded thymol during 6 days, shorter impregnation process resulted in sutures that retained significant thymol amounts (similar to 20-40%) after 10 days of release test. The effect of proposed process on final material properties and its application were explained in detail using characterization techniques SEM, FTIR, DSC and DMA. |
| Databáze: | OpenAIRE |
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