Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma
| Autor: | Jerzy Starzyk, Ł. Wyrobek, Anna Wędrychowicz, Małgorzata Wójcik, D. Roztoczyńska, P. Sołtysiak, Dominika Januś, Grażyna Drabik, A. Taczanowska |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Normoechogenic background of thyroid gland
Adult Male Thyroid nodules medicine.medical_specialty Autoimmune thyroiditis Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism Thyroid Gland normoechogenic background of thyroid gland 030209 endocrinology & metabolism Thyroid carcinoma Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Fibrosis ultrasonography of thyroid gland medicine Humans Thyroid Neoplasms Child Parenchymal Tissue Retrospective Studies Ultrasonography business.industry Ultrasound Thyroid Thyroiditis Autoimmune Echogenicity Nodule (medicine) autoimmune thyroiditis Prognosis medicine.disease Carcinoma Papillary medicine.anatomical_structure Papillary thyroid carcinoma Child Preschool 030220 oncology & carcinogenesis papillary thyroid carcinoma Original Article Female Radiology medicine.symptom business Ultrasonography of thyroid gland Follow-Up Studies |
| Zdroj: | Journal of Endocrinological Investigation |
| Popis: | Purpose To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not have a thyroid nodule on admission but developed papillary thyroid carcinoma (PTC) and to characterize the parenchymal changes in the thyroid gland prior to the development of PTC. Methods A retrospective thyroid US scan review of 327 patients diagnosed with AIT was performed. Forty patients (40/327, 12.2%) presented nodular AIT variant with a normoechogenic background. Eleven patients (11/327, 3.4%, 11/40, 27.5%) presenting this variant were diagnosed with PTC (nine females—mean age 15.3 years; two males aged 11 and 13 years). In five of 11 patients, the suspicious nodule that was later confirmed to be PTC was detected on the initial US at presentation. For the remaining six females (6/11) who developed PTC during the follow-up, we retrospectively analysed their US thyroid scans and these patients were selected for analysis in this study. Results On admission, the US evaluation revealed an enlarged normoechogenic thyroid gland in three patients and a hypoechogenic thyroid gland with fibrosis as indicated by irregular, chaotic hyperechogenic layers in three patients. No thyroid nodules were identified. Ultrasound monitoring revealed increasing echogenicity of the thyroid parenchyma during the follow-up. PTC developed in a mean time of 4.6 years (1 9/12–7 4/12 years) since referral to the outpatient thyroid clinic and 2.9 years (6/12–6 9/12) since the last nodule-free US thyroid scan. Conclusions Sonographic follow-up assessments warrant further exploration as a strategy to determine PTC susceptibility in the paediatric population. |
| Databáze: | OpenAIRE |
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