Environmental xenobiotics and nuclear receptors—Interactions, effects and in vitro assessment
| Autor: | Ivan Holoubek, Klára Hilscherová, Jaroslav Janošek, Luděk Bláha |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Aryl hydrocarbon receptor nuclear translocator Receptors Cytoplasmic and Nuclear Peroxisome proliferator-activated receptor Endocrine Disruptors In Vitro Techniques 010501 environmental sciences Retinoid X receptor Biology Toxicology medicine.disease_cause 01 natural sciences Xenobiotics 03 medical and health sciences Internal medicine Toxicity Tests medicine Animals Humans Receptor Transcription factor 030304 developmental biology 0105 earth and related environmental sciences chemistry.chemical_classification 0303 health sciences General Medicine 3. Good health Cell biology Endocrinology chemistry Nuclear receptor Environmental Pollutants Signal transduction Carcinogenesis |
| Zdroj: | Toxicology in Vitro. 20:18-37 |
| ISSN: | 0887-2333 |
| Popis: | A group of intracellular nuclear receptors is a protein superfamily including arylhydrocarbon AhR, estrogen ER, androgen AR, thyroid TR and retinoid receptors RAR/RXR as well as molecules with unknown function known as orphan receptors. These proteins play an important role in a wide range of physiological as well as toxicological processes acting as transcription factors (ligand-dependent signalling macromolecules modulating expression of various genes in a positive or negative manner). A large number of environmental pollutants and other xenobiotics negatively affect signaling pathways, in which nuclear receptors are involved, and these modulations were related to important in vivo toxic effects such as immunosuppression, carcinogenesis, reproduction or developmental toxicity, and embryotoxicity. Presented review summarizes current knowledge on major nuclear receptors (AhR, ER, AR, RAR/RXR, TR) and their relationship to known in vivo toxic effects. Special attention is focused on priority organic environmental contaminants and experimental approaches for determination and studies of specific toxicity mechanisms. |
| Databáze: | OpenAIRE |
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