Early detection of anthracycline-induced cardiotoxicity in long-term survivors of acute lymphoblastic leukemia treated with low cumulative dose
| Autor: | Fortuna Del Gaizo, Giovanni Di Salvo, Maria Giovanna Russo, Fabio D'Aiello, Diana Iarussi, Paolo Indolfi, Raffaele Calabrò, Maria Teresa di Tullio, Fiorina Casale |
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| Přispěvatelé: | Salvo, Gd, D'Aniello, F, Gaizo, Fd, Indolfi, Paolo, Casale, F, Di Tullio, Mt, Iarussi, D, Calabrò, R, Russo, Mg. |
| Rok vydání: | 2014 |
| Předmět: |
Anthracycline cardiomyopathy
SR imaging ventricular function medicine.medical_specialty Cumulative dose business.industry Lymphoblastic Leukemia Healthy subjects Early detection Anthracycline cardiomyopathy SR imaging Parasternal line Internal medicine medicine Cardiology ventricular function Original Article Radiology Nuclear Medicine and imaging Myocardial Performance Index Cardiology and Cardiovascular Medicine Anthracycline induced cardiotoxicity business Subclinical infection |
| Zdroj: | Journal of Cardiovascular Echography |
| ISSN: | 2211-4122 |
| DOI: | 10.4103/2211-4122.132282 |
| Popis: | We investigated the left ventricular (LV) function, using for the first time strain (S) and strain rate (SR) imaging, in long-term survivors affected by acute lymphoblastic leukemia treated with a low cumulative dose of anthracyclines, and in presence of a normal global LV systolic and diastolic function. A total of 21 were enrolled in the study. The mean cumulative dose of anthracylines was 180 mg/m2 (range: 120-210 mg/m2). As control group 21 age-sex matched healthy subjects were included. Radial S (17 ± 3% vs. 55 ± 6%, P < 0.0001) and SR (2.1 ± 0.3 vs. 3.0 ± 0.8 1\s, P < 0.0001), assessed on the midsegment of the posterior wall from the parasternal views were significantly reduced when compared with controls. Conversely, myocardial performance index was not able to discriminate between patients and controls. In this preliminary study, the myocardial deformation indices appear to be a more sensitive noninvasive technique for detecting subclinical LV dysfunction than other echocardiographic measurements. |
| Databáze: | OpenAIRE |
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