Elevated CA125 level associated with Meigs’ syndrome: case report and review of the literature
| Autor: | Germán Calderillo-Ruiz, Carlos M. López-Graniel, Dolores Gallardo-Rincón, A. Morán-Mendoza, G. Alvarado-Luna, Alberto Serrano-Olvera |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Paclitaxel endocrine system diseases Pleural effusion Antineoplastic Agents Adenocarcinoma Vinblastine Malignancy Deoxycytidine Carboplatin Ovarian tumor Gynecologic Surgical Procedures Ascites medicine Humans Meigs Syndrome Meigs' syndrome Ovarian fibroma business.industry Obstetrics and Gynecology Vinorelbine Middle Aged medicine.disease Gemcitabine female genital diseases and pregnancy complications Surgery Oncology CA-125 Antigen Female Radiology Fibroma medicine.symptom Ovarian cancer business |
| Zdroj: | International Journal of Gynecological Cancer. 16:315-318 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1111/j.1525-1438.2006.00228.x |
| Popis: | Meigs' syndrome is the association of ovarian fibroma, pleural effusion, and ascites. Meigs' syndrome with marked elevation of CA125 is an unusual clinical condition reported in 27 cases in the literature. The patient was a 46-year-old woman with right pleural effusion, ascites, ovarian tumor, and CA125 level of 1808 U/mL. Tomography revealed ascites and bilobate pelvic tumor of approximately 25 cm. The diagnosis of advanced epithelial ovarian cancer was considered, and the patient was treated with chemotherapy. Three chemotherapy schemes were applied due to the total lack of response in tumor volume; however, CA125 decreased to 90 U/mL. Thus, surgery was performed with resection of 25 cm of the left ovarian tumor, with intact capsule and without implants; the result of histopathologic analysis was fibroma. Postoperative CA125 was 11 U/mL. Patients with elevated CA125 and ascites cytology positive for malignancy must be cautiously treated due to the possibility of false positives, even if the probability is low. Therefore, minimally invasive surgery for biopsy collection must be considered. Although the association between ovarian tumor, pleural effusion, ascites, and marked elevation of CA125 is highly indicative of epithelial ovarian cancer, Meigs' syndrome must be considered in the differential diagnosis. |
| Databáze: | OpenAIRE |
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