Atypical angioimmunoblastic T-cell lymphomas masquerading as systemic polyclonal B-immunoblastic proliferation
| Autor: | Jacek M. Polski, David Roland Clarkson, Theresa O. Liu-Dumlao, Bhavesh Papadi |
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| Rok vydání: | 2012 |
| Předmět: |
Angioimmunoblastic T-cell lymphoma
Pathology medicine.medical_specialty T cell Plasma Cells Plasma cell Pathology and Forensic Medicine Diagnosis Differential Neoplasms Multiple Primary Recurrence Antineoplastic Combined Chemotherapy Protocols medicine Humans Secretion Molecular Biology B cell Aged Bone Marrow Transplantation B-Lymphocytes biology Plasmacytosis Lymphoma T-Cell Peripheral Cell Biology General Medicine Middle Aged medicine.disease Combined Modality Therapy Peripheral T-cell lymphoma Treatment Outcome medicine.anatomical_structure Polyclonal antibodies Immunoblastic Lymphadenopathy biology.protein Female Stem Cell Transplantation |
| Zdroj: | Virchows Archiv. 461:323-331 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-012-1280-5 |
| Popis: | Angioimmunoblastic T cell lymphoma (AITL) is a relatively rare peripheral T cell lymphoma derived from follicular T helper cells. AITL has a varied presentation, both clinically and morphologically. AITL can pose a diagnostic challenge as it may be difficult to identify and characterize the neoplastic cells among the polymorphous infiltrates composed of polyclonal B immunoblasts and plasma cells. In AITL, the reactive B cell and plasma cell proliferation is secondary to dysregulated secretion of cytokines such as interleukin-6 by the neoplastic follicular T helper cells. SPBIP is a condition of unknown etiopathogenesis characterized by systemic involvement by polyclonal B immunoblasts and plasma cells. We report two cases of AITL, which are presented with atypical findings making it difficult to diagnose. The cases had features similar to SPBIP. Our cases highlight the importance of screening cases of polyclonal plasmacytosis and SPBIP like cases for underlying AITL. |
| Databáze: | OpenAIRE |
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