Graves' disease induced by Na131I therapy for toxic multinodular goitre
| Autor: | L.J.M. de Heide, M.A.L Edelbroek, M.A Talsma, J.J van Leussen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
endocrine system
medicine.medical_specialty Pediatrics Time Factors endocrine system diseases Graves' disease medicine.medical_treatment Anti-Inflammatory Agents Disease Drug Administration Schedule Iodine Radioisotopes Prednisone Immunopathology Internal Medicine medicine Humans Toxic multinodular goitre Radionuclide Imaging Autoimmune disease business.industry Middle Aged medicine.disease Graves Disease eye diseases Surgery Radiation therapy Female business Complication Goiter Nodular medicine.drug |
| Zdroj: | The Netherlands Journal of Medicine. 57:194-197 |
| ISSN: | 0300-2977 |
| DOI: | 10.1016/s0300-2977(00)00068-1 |
| Popis: | A 59-year-old woman developed manifestations of Graves’ disease several months after treatment with radioiodine (Na 131 I) for toxic multinodular goitre. During subsequent treatment with additional radioiodine therapy Graves’ ophthalmopathy developed which was severe and required treatment with prednisone and orbital radiotherapy. The literature on development of Graves’ disease following Na 131 I therapy is reviewed and possible pathophysiological mechanisms are discussed. In this case, possibly the first radioiodine therapy has illicited Graves’ thyrotoxicosis and the subsequently added radioiodine treatments for the persistent Graves’ thyrotoxicosis led to serious ophthalmopathy. Physicians should recognise Graves’-like disease as a complication of Na 131 I therapy for toxic multinodular goitre and carefully consider the timing of consecutive radioiodine therapy. |
| Databáze: | OpenAIRE |
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