Combination chemotherapy of malignant glioma. Effect of postoperative treatment with CCNU, vincristine, amethopterine and procarbazine
| Autor: | B. Mamoli, W.-D. Heiss, M. Turnheim |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Adult
Vincristine medicine.medical_specialty Adolescent Side effect Procarbazine Nitrosourea Compounds Pharmacotherapy Lomustine Postoperative treatment Glioma medicine Humans Postoperative Period Aged Brain Neoplasms business.industry Peripheral Nervous System Diseases Combination chemotherapy General Medicine Middle Aged medicine.disease Surgery Methotrexate Drug Therapy Combination Neoplasm Recurrence Local business Median survival medicine.drug |
| Zdroj: | European Journal of Cancer (1965). 14:1191-1202 |
| ISSN: | 0014-2964 |
| DOI: | 10.1016/0014-2964(78)90225-6 |
| Popis: | A combination chemotherapy consisting of CCNU, vincristine, amethopterine and procarbazine (COMP-therapy) was studied in the postoperative treatment of malignant gliomas. Fifteen-day COMP-therapy series given 10–20 days after surgery and repeated at regular intervals increased the median recurrence-free interval to 8.9 months and the median survival time to 10.7 months. Both prolongations were significant when compared to the results in a control group not receiving postoperative chemotherapy (median recurrence-free interval: 2.6 months, median survival time: 6.2 months), in a group receiving postoperative CCNU-treatment ( 3.5 and 6.5 months, respectively), and to a group of patients treated with postoperative polychemotherapy ( 4.7 and 8.0 months, respectively). The only problematic side effect of COMP-therapy was neuropathy resulting from toxic vincristine-dosage. While nitrosoureas alone were not able to affect the length and the quality of survival, their combination with cell-cycle specific and other cell-cycle non-specific drugs improved the results in the therapy of primary malignant brain tumors. |
| Databáze: | OpenAIRE |
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