Monoclonal gammopathy of undetermined significance (MGUS) manifestation in CNS: a regular or chance occurrence?
| Autor: | L. N. Prakhova, Aleksandr G Ilves, Yulia Nazinkina, Valeriy Lebedev |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Central Nervous System
0301 basic medicine medicine.medical_specialty Neurology Central nervous system Paraproteinemias Case Report CNS Involvement Bioinformatics Monoclonal Gammopathy of Undetermined Significance 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Humans Medicine In patient Stage (cooking) business.industry General Medicine medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Peripheral nervous system Multiple Myeloma business Monoclonal gammopathy of undetermined significance Haematological disorders |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2020-237726 |
| Popis: | Monoclonal gammopathy of undetermined significance (MGUS)-associated involvement of the peripheral nervous system is widely reported in the literature. At the same time, involvement of central nervous system (CNS) occurs far less frequently. Analysing the reported cases, almost all the authors pose the question whether there is a relationship between CNS involvement and MGUS, and at what stage it is necessary to begin therapy of haematological disorders. The limited number of reported cases precludes us from getting a definite answer to these questions, thus making further accumulation of clinical data highly relevant. In this article, we present two cases of CNS involvement in patients with MGUS, which, in our opinion, may suggest the existence of a causal relationship between MGUS and CNS involvement. Currently, the above hypothesis cannot be taken as proved due to the lack of a sufficient number of clinical observations and scientific studies. Therefore, the issue of MGUS-associated CNS involvement requires further research. |
| Databáze: | OpenAIRE |
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