Genetic and Environmental Factors Associated With the Ganglion Cell Complex in a Healthy Aging British Cohort
| Autor: | Diana Kozareva, Eneh Jones-Odeh, Edward Bloch, Katie M Williams, Ekaterina Yonova-Doing, Christopher J Hammond |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Retinal Ganglion Cells medicine.medical_specialty Adolescent Population Twins Renal function Gastroenterology Young Adult 03 medical and health sciences Nerve Fibers 0302 clinical medicine Risk Factors Internal medicine Diseases in Twins medicine Humans Genetic Predisposition to Disease education Aged Aged 80 and over education.field_of_study business.industry Glaucoma Environmental Exposure Environmental exposure Middle Aged Stepwise regression Heritability Twin study United Kingdom Ophthalmology Cross-Sectional Studies Endocrinology Cohort 030221 ophthalmology & optometry Female business Body mass index Tomography Optical Coherence 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Bloch, E, Yonova-Doing, E, Jones-Odeh, E, Williams, K M, Kozareva, D & Hammond, C J 2016, ' Genetic and Environmental Factors Associated With the Ganglion Cell Complex in a Healthy Aging British Cohort ', JAMA Ophthalmology . https://doi.org/10.1001/jamaophthalmol.2016.4486 |
| Popis: | Importance: Measurement of ganglion cell complex (GCC) thickness may be more sensitive than current methods for glaucoma diagnosis and research. However, little is known about the factors influencing GCC thickness in the general population.Objectives: To investigate the heritability of and factors associated with GCC thickness in a healthy aging population.Design, Setting, and Participants: A cross-sectional twin study was conducted from August 27, 2014, to March 31, 2016, among 1657 participants of white British ancestry from the TwinsUK study cohort without ocular pathologic conditions. Heritability analyses were conducted in 1432 twins (426 monozygous and 290 dizygous pairs). Association analyses were performed using univariable and multivariable stepwise linear regression models, taking family structure into account. Heritability analyses were conducted using maximum likelihood structural equation twin modeling.Main Outcomes and Measures: Parameters measured included GCC thickness, autorefraction, intraocular pressure, blood pressure, body mass index, and cholesterol, creatinine, glucose, insulin, triglycerides, and urea levels. Estimated glomerular filtration rate was calculated using the Modification of Diet in Renal Disease formula.Results: Among the 1657 participants (mean [SD] age, 56.0 [15.3] years; 89.5% women and 10.5% men), the mean [SD] inner GCC thickness was 96.0 [7.6] μm (95% CI, 95.1-96.2). In multivariable modeling, the mean inner GCC thickness was associated with advancing age (β, -0.14; P Conclusions and Relevance: Ganglion cell complex thickness appears to be highly heritable and further genetic analysis may help identify new biological pathways for glaucoma. The results suggest it may be important to account for age, body mass index, refractive error, and sex when using GCC thickness as a diagnostic tool. Replication of their results is required, as is further research to explain the association between renal function and GCC thickness. |
| Databáze: | OpenAIRE |
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