Blocking mineralocorticoid receptors impairs, blocking glucocorticoid receptors enhances memory retrieval in humans
| Autor: | Tanja Lange, Jan Born, Luciana Besedovsky, Ulrike Rimmele |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Time Factors mifepristone Neuropsychological Tests Spironolactone Spironolactone/pharmacology memory receptor pharmacology chemistry.chemical_compound 0302 clinical medicine Glucocorticoid receptor Mineralocorticoid receptor Mineralocorticoid Receptor Antagonists/pharmacology glucocorticoid receptor learning & memory Mifepristone/pharmacology Mental Recall/drug effects/physiology Receptor Mineralocorticoid Receptor Antagonists 0303 health sciences Mifepristone Psychiatry and Mental health Sleep/drug effects Original Article Psychology medicine.drug Adult medicine.medical_specialty Adolescent medicine.drug_class Receptors Glucocorticoid/drug effects Receptors Mineralocorticoid/drug effects behavioral science cortisol 03 medical and health sciences Young Adult Hormone Antagonists Receptors Glucocorticoid Double-Blind Method Internal medicine medicine Humans 030304 developmental biology mineralocorticoid receptor Pharmacology psychopharmacology ddc:616.8 Blockade Endocrinology Free recall Receptors Mineralocorticoid chemistry Mineralocorticoid Hormone Antagonists/pharmacology Mental Recall Sleep 030217 neurology & neurosurgery Photic Stimulation |
| Zdroj: | Neuropsychopharmacology Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Neuropsychopharmacology, Vol. 38, No 5 (2013) pp. 884-94 |
| ISSN: | 1740-634X |
| Popis: | Memory retrieval is impaired at very low as well as very high cortisol levels, but not at intermediate levels. This inverted-U-shaped relationship between cortisol levels and memory retrieval may originate from different roles of the mineralocorticoid (MR) and glucocorticoid receptor (GR) that bind cortisol with distinctly different affinity. Here, we examined the role of MRs and GRs in human memory retrieval using specific receptor antagonists. In two double-blind within-subject, cross-over designed studies, young healthy men were asked to retrieve emotional and neutral texts and pictures (learnt 3 days earlier) between 0745 and 0915 hours in the morning, either after administration of 400 mg of the MR blocker spironolactone vs placebo (200 mg at 2300 hours and 200 mg at 0400 hours, Study I) or after administration of the GR blocker mifepristone vs placebo (200 mg at 2300 hours, Study II). Blockade of MRs impaired free recall of both texts and pictures particularly for emotional material. In contrast, blockade of GRs resulted in better memory retrieval for pictures, with the effect being more pronounced for neutral than emotional materials. These findings indicate indeed opposing roles of MRs and GRs in memory retrieval, with optimal retrieval at intermediate cortisol levels likely mediated by high MR but concurrently low GR activation. |
| Databáze: | OpenAIRE |
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