Sacroiliac radiographic progression in recent onset axial spondyloarthritis: the 5-year data of the DESIR cohort

Autor: Anna Molto, Manouk de Hooge, Sofia Ramiro, Alexandre Sepriano, Maxime Dougados, Rosaline van den Berg, Victoria Navarro Compan, C. Demattei, Miranda van Lunteren, Désirée van der Heijde, Robert Landewé
Přispěvatelé: Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Hôpital Cochin [AP-HP], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Leiden University Medical Center (LUMC), Department of Rheumatology and Clinical Epidemiology, Leiden University Medical Center (LUMC), Department of Rheumatology (LEIDEN - Rhumato), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Dpt of Clinical Immunology & Rheumatology [Amsterdam], Amsterdam and Atrium Medical Center, Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), CHU Cochin [AP-HP], Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM)-Université Montpellier 1 (UM1), AII - Inflammatory diseases, Clinical Immunology and Rheumatology, AII - Amsterdam institute for Infection and Immunity
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Time Factors
Radiography
[SDV]Life Sciences [q-bio]
Severity of Illness Index
Cohort Studies
0302 clinical medicine
Epidemiology
Immunology and Allergy
Axial spondyloarthritis
HLA-B27 Antigen
ComputingMilieux_MISCELLANEOUS
Sacroiliac joint
medicine.diagnostic_test
spondyloarthritis
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
[SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Disease Progression
epidemiology
Female
France
musculoskeletal diseases
Adult
medicine.medical_specialty
Adolescent
Immunology
General Biochemistry
Genetics and Molecular Biology
outcomes research
03 medical and health sciences
Young Adult
Rheumatology
Internal medicine
Spondylarthritis
medicine
Humans
Sacroiliitis
Recent onset
030203 arthritis & rheumatology
business.industry
Magnetic resonance imaging
Sacroiliac Joint
Clinical and Epidemiological Research
medicine.disease
Surgery
030104 developmental biology
Outcomes research
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2017, 76 (11), pp.1823-1828. ⟨10.1136/annrheumdis-2017-211596⟩
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2017, 76 (11), pp.1823-1828
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Annals of the Rheumatic Diseases, 76(11), 1823-1828
Annals of the rheumatic diseases, 76(11), 1823-1828. BMJ Publishing Group
ISSN: 0003-4967
1468-2060
DOI: 10.1136/annrheumdis-2017-211596⟩
Popis: ObjectiveTo estimate sacroiliac joint radiographic (X-SIJ) progression in patients with axial spondyloarthritis (axSpA) and to evaluate the effects of inflammation on MRI (MRI-SIJ) on X-SIJ progression.MethodsX-SIJ and MRI-SIJ at baseline and after 2 and 5 years in patients with recent onset axSpA from the DESIR cohort were scored by three central readers. Progression was defined as (1) the shift from non-radiographic (nr) to radiographic (r) sacroiliitis (by modified New York (mNY) criteria) or alternative criteria, (2) a change of at least one grade or (3) a change of at least one grade but ignoring a change from grade 0 to 1. The effects of baseline inflammation on MRI-SIJ on 5-year X-SIJ damage (mNY) were tested by generalised estimating equations.ResultsIn 416 patients with pairs of baseline and 5-year X-SIJ present, net progression occurred in 5.1% (1), 13.0% (2) and 10.3% (3) respectively, regarding a shift from nr-axSpA to r-axSpA (1), a change of at least one grade (2) or a change of at least one grade but ignoring a change from grade 0 to 1 (3). Baseline MRI-SIJ predicted structural damage after 5 years in human leukocyte antigen-B27 (HLA-B27) positive (OR 5.39 (95% CI 3.25 to 8.94)) and in HLA-B27 negative (OR 2.16 (95% CI 1.04 to 4.51)) patients.ConclusionsFive-year progression of X-SIJ damage in patients with recent onset axSpA is limited but present beyond measurement error. Baseline MRI-SIJ inflammation drives 5-year radiographic changes.
Databáze: OpenAIRE
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