Assignment of the native Chinese hamster dihydrofolate reductase gene to chromosome 2
| Autor: | Frank H. Ruddle, J.T. Hart, M. Roberts, Joseph P. Davide, P.W. Melera |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Genetic Linkage
Somatic cell Drug Resistance Hamster Hybrid Cells Biology Chinese hamster Cricetulus Gene mapping Cricetinae Genetics Animals education Molecular Biology Gene Homogeneously Staining Region Genetics (clinical) education.field_of_study Chinese hamster ovary cell Chromosome Mapping Nucleic Acid Hybridization Chromosome biology.organism_classification Molecular biology Tetrahydrofolate Dehydrogenase Methotrexate Karyotyping |
| Zdroj: | Cytogenetic and Genome Research. 36:599-604 |
| ISSN: | 1424-859X 1424-8581 |
| DOI: | 10.1159/000131982 |
| Popis: | The native Chinese hamster DHFR gene was localized to 2pter^-ql4 using a combination of somatic cell hybrid technology and molecular techniques. In addition, PGD, ENOJ, and DTS, previously mapped to Chinese hamster chromosome 2, were localized to 2ql4— > qter. Localization of PGM1 to this region was confirmed. The relationship of the site of the native DHFR gene to the location of the homogeneously staining region in methotrexate-resistant cells is discussed. |
| Databáze: | OpenAIRE |
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