Assessment of the cough reflex after propofol anaesthesia for colonoscopy
| Autor: | Jean Guglielminotti, F. Mentré, T. Rackelboom, Antoine Tesniere, X Panhard, Jean-Marie Desmonts, Jean Mantz, Marcel Bonay |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cough reflex Sedation Colonoscopy Aspiration pneumonia Pneumonia Aspiration Citric Acid Reflex medicine Humans General anaesthesia Propofol Dose-Response Relationship Drug medicine.diagnostic_test Inhalation business.industry Middle Aged medicine.disease Pneumonia Anesthesiology and Pain Medicine Cough Anesthesia Anesthesia Recovery Period Female medicine.symptom business Anesthetics Intravenous medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 95:406-409 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/aei175 |
| Popis: | Background. Dysfunction of the cough reflex as a result of the lingering effects of anaesthetics may lead to aspiration pneumonia or retained secretions after general anaesthesia. It is unknown whether low concentrations of propofol alter the cough reflex in the early period after anaesthesia. The objective of this study was to investigate the effect of low concentrations of propofol on the cough reflex sensitivity as assessed by the cough reflex threshold to an inhaled irritant. Methods.Fifteen,ASAI‐II,non-smokingpatientsundergoingelectivecolonoscopywerestudied. Anaesthesia was induced and maintained with a blood target-controlled propofol infusion. Cough reflex threshold was measured with citric acid. Increasing concentrations of nebulized citric acid (2.5, 5, 10, 20, 40, 80, 160, 320, and 640 mg ml 1 ) were delivered during inspiration until a cough wasevoked.Thecitric acid concentrationeliciting onecough(C1) wasdefinedas thecoughreflex threshold. C1 was log transformed for statistical analysis (Log C1). Log C1 was measured before anaesthesia and during the recovery period with estimated decreasing propofol concentrations of 1.2, 0.9, 0.6, and 0.3 m gm l 1 . Results. Log C1 (median; interquartile range) measured with propofol concentrations of 1.2, 0.9, 0.6, 0.3, and 0 m gm l 1 were 1.9 (0.6), 1.9 (1.0), 1.9 (1.1), 1.9 (0.6), and 1.9 (0.7) mg ml 1 (NS), respectively. However, light sedation was observed with propofol concentrations of 1.2 and 0.9 m gm l 1 . Conclusion. This study indicates that residual sedation after propofol anaesthesia for colonoscopy does not adversely affect the cough reflex. Br J Anaesth 2005; 95: 406‐9 |
| Databáze: | OpenAIRE |
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